38441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 378450..379798 Replicon chromosome
Accession NZ_AP024414
Organism Haemophilus influenzae strain TA8730

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag JUD77_RS01870 Protein ID WP_005667626.1
Coordinates 378767..379798 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag JUD77_RS01865 Protein ID WP_005667629.1
Coordinates 378450..378770 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUD77_RS01825 373872..374150 + 279 WP_103708107.1 cell division protein FtsB -
JUD77_RS01830 374150..374827 + 678 WP_114877243.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
JUD77_RS01835 374824..375300 + 477 WP_005650817.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
JUD77_RS01840 375606..376040 - 435 WP_006995247.1 D-tyrosyl-tRNA(Tyr) deacylase -
JUD77_RS01845 376037..376477 - 441 WP_005667635.1 FMN-binding protein MioC -
JUD77_RS01850 376574..376792 - 219 WP_005650820.1 cell division protein ZapB -
JUD77_RS01855 376954..377955 + 1002 WP_005667633.1 class II fructose-bisphosphatase -
JUD77_RS01860 378154..378462 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
JUD77_RS01865 378450..378770 + 321 WP_005667629.1 type II toxin-antitoxin system HipA family toxin Antitoxin
JUD77_RS01870 378767..379798 + 1032 WP_005667626.1 type II toxin-antitoxin system HipA family toxin Toxin
JUD77_RS01875 379881..381539 - 1659 WP_103708105.1 thiol reductant ABC exporter subunit CydC -
JUD77_RS01880 381532..383277 - 1746 WP_103708104.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39869.52 Da        Isoelectric Point: 6.4431

>T38441 WP_005667626.1 NZ_AP024414:378767-379798 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSINQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKIAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFYTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLHEPEL

Download         Length: 1032 bp

>T38441 NZ_AP024414:378767-379798 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAAATTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTTA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACCTATTACATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12457.11 Da        Isoelectric Point: 5.9670

>AT38441 WP_005667629.1 NZ_AP024414:378450-378770 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT38441 NZ_AP024414:378450-378770 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References