Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4674145..4674899 | Replicon | chromosome |
| Accession | NZ_AP024347 | ||
| Organism | Salmonella enterica strain SEOhiM1593 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A3V5VZY0 |
| Locus tag | QMN54_RS22675 | Protein ID | WP_023259289.1 |
| Coordinates | 4674145..4674456 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | QMN54_RS22680 | Protein ID | WP_001259011.1 |
| Coordinates | 4674453..4674899 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMN54_RS22645 (SAML1593_43400) | 4669803..4670705 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| QMN54_RS22650 (SAML1593_43410) | 4670702..4671337 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| QMN54_RS22655 (SAML1593_43420) | 4671334..4672263 | + | 930 | WP_023259287.1 | formate dehydrogenase accessory protein FdhE | - |
| QMN54_RS22660 (SAML1593_43430) | 4672310..4672600 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| QMN54_RS22665 (SAML1593_43440) | 4672601..4672912 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| QMN54_RS22670 (SAML1593_43450) | 4673130..4674059 | + | 930 | WP_052940738.1 | alpha/beta hydrolase | - |
| QMN54_RS22675 (SAML1593_43460) | 4674145..4674456 | + | 312 | WP_023259289.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| QMN54_RS22680 (SAML1593_43470) | 4674453..4674899 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| QMN54_RS22685 (SAML1593_43480) | 4674914..4675855 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| QMN54_RS22690 (SAML1593_43490) | 4675900..4676337 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| QMN54_RS22695 (SAML1593_43500) | 4676334..4677206 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| QMN54_RS22700 (SAML1593_43510) | 4677200..4677799 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| QMN54_RS22705 (SAML1593_43520) | 4677990..4678793 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| QMN54_RS22710 (SAML1593_43530) | 4678827..4679723 | - | 897 | WP_023259290.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12440.38 Da Isoelectric Point: 9.5921
>T38426 WP_023259289.1 NZ_AP024347:4674145-4674456 [Salmonella enterica]
VHVISRKPFNEAMFMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMFMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T38426 NZ_AP024347:4674145-4674456 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCAATGTTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCAATGTTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT38426 WP_001259011.1 NZ_AP024347:4674453-4674899 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT38426 NZ_AP024347:4674453-4674899 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|