Detailed information of TA system TA038425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4672310..4672912
• Replicon: chromosome
• Accession: NZ_AP024347
• Organism: Salmonella enterica strain SEOhiM1593

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: QMN54_RS22665
• Protein ID: WP_001159630.1
• Coordinates: 4672601..4672912 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: QMN54_RS22660
• Protein ID: WP_000362050.1
• Coordinates: 4672310..4672600 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMN54_RS22645 (SAML1593_43400)	4669803..4670705	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
QMN54_RS22650 (SAML1593_43410)	4670702..4671337	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
QMN54_RS22655 (SAML1593_43420)	4671334..4672263	+	930	WP_023259287.1	formate dehydrogenase accessory protein FdhE	-
QMN54_RS22660 (SAML1593_43430)	4672310..4672600	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
QMN54_RS22665 (SAML1593_43440)	4672601..4672912	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
QMN54_RS22670 (SAML1593_43450)	4673130..4674059	+	930	WP_052940738.1	alpha/beta hydrolase	-
QMN54_RS22675 (SAML1593_43460)	4674145..4674456	+	312	WP_023259289.1	type II toxin-antitoxin system HigB family toxin	-
QMN54_RS22680 (SAML1593_43470)	4674453..4674899	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
QMN54_RS22685 (SAML1593_43480)	4674914..4675855	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
QMN54_RS22690 (SAML1593_43490)	4675900..4676337	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
QMN54_RS22695 (SAML1593_43500)	4676334..4677206	-	873	WP_000921423.1	virulence factor BrkB family protein	-
QMN54_RS22700 (SAML1593_43510)	4677200..4677799	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T38425 WP_001159630.1 NZ_AP024347:c4672912-4672601 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T38425 NZ_AP024347:c4672912-4672601 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT38425 WP_000362050.1 NZ_AP024347:c4672600-4672310 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT38425 NZ_AP024347:c4672600-4672310 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAGATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64