Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1898874..1899472 Replicon chromosome
Accession NZ_AP024333
Organism Erwinia rhapontici strain MAFF 311155

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI232_RS09050 Protein ID WP_133843476.1
Coordinates 1898874..1899155 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI232_RS09055 Protein ID WP_133843073.1
Coordinates 1899155..1899472 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI232_RS09035 (ERHA55_19530) 1894749..1895819 + 1071 WP_133843067.1 LacI family DNA-binding transcriptional regulator -
KI232_RS09040 (ERHA55_19540) 1895873..1896874 - 1002 WP_133843069.1 substrate-binding domain-containing protein -
KI232_RS09045 1896884..1898490 - 1607 Protein_1780 methyl-accepting chemotaxis protein -
KI232_RS09050 (ERHA55_19570) 1898874..1899155 + 282 WP_133843476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI232_RS09055 (ERHA55_19580) 1899155..1899472 + 318 WP_133843073.1 HigA family addiction module antitoxin Antitoxin
KI232_RS09060 (ERHA55_19590) 1899544..1900818 - 1275 WP_159337011.1 enterobactin transporter EntS -
KI232_RS09065 1901058..1902013 + 956 Protein_1784 Fe(3+)-siderophore ABC transporter permease -
KI232_RS09070 1902024..1903057 + 1034 Protein_1785 iron-enterobactin ABC transporter permease -
KI232_RS09075 (ERHA55_19650) 1903060..1903881 + 822 WP_133843081.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11029.53 Da        Isoelectric Point: 9.3752

>T38392 WP_133843476.1 NZ_AP024333:1898874-1899155 [Erwinia rhapontici]
VIKSWKHKGLQKLFETGNPSGVQAKDAERIRTRLLVLDEALSVEEFRNYPGFRFHPLKGDRQYLYAITVRANWRITFEFR
DGDAYILNLEDYH

Download         Length: 282 bp

>T38392 NZ_AP024333:1898874-1899155 [Erwinia rhapontici]
GTGATCAAAAGCTGGAAGCATAAGGGATTGCAAAAACTGTTCGAAACAGGAAATCCCAGTGGTGTGCAGGCCAAAGATGC
CGAACGGATCAGAACGCGTCTGCTGGTTCTTGACGAAGCCCTGTCGGTAGAAGAATTCAGAAACTACCCTGGCTTCAGGT
TCCATCCGCTGAAAGGCGACAGGCAGTATCTTTACGCCATTACTGTTCGTGCCAACTGGCGTATCACTTTCGAGTTCAGA
GACGGTGATGCTTACATACTTAATCTGGAGGACTACCACTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11153.84 Da        Isoelectric Point: 4.6854

>AT38392 WP_133843073.1 NZ_AP024333:1899155-1899472 [Erwinia rhapontici]
MAMMTPPHPGSLITEYLEDYNVSLRTLAGNLGVSPSALSKAAAGKTAITPEMAVRLEAGLGIAARLWLAMQATYDISRVR
ETIDITQVVPACYDETDGQPVKTCG

Download         Length: 318 bp

>AT38392 NZ_AP024333:1899155-1899472 [Erwinia rhapontici]
ATGGCTATGATGACCCCCCCGCATCCGGGCAGCCTGATTACCGAGTATCTTGAGGACTATAACGTCAGCCTGCGGACGCT
GGCCGGAAACCTCGGGGTATCCCCCTCGGCGTTGAGCAAAGCGGCGGCAGGAAAAACCGCTATTACCCCTGAAATGGCGG
TACGGCTGGAAGCCGGGCTGGGCATTGCGGCCCGTCTCTGGCTGGCGATGCAGGCAACGTACGATATTAGCCGGGTCCGC
GAAACGATTGATATCACGCAGGTCGTGCCCGCCTGCTATGACGAAACCGATGGTCAGCCAGTGAAGACCTGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References