Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1899260..1899858 Replicon chromosome
Accession NZ_AP024329
Organism Erwinia rhapontici strain MAFF 311153

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KJS81_RS08965 Protein ID WP_133843476.1
Coordinates 1899260..1899541 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KJS81_RS08970 Protein ID WP_133843073.1
Coordinates 1899541..1899858 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS81_RS08950 (ERHA53_17700) 1895134..1896204 + 1071 WP_133843067.1 LacI family DNA-binding transcriptional regulator -
KJS81_RS08955 (ERHA53_17710) 1896258..1897259 - 1002 WP_133843069.1 substrate-binding domain-containing protein -
KJS81_RS08960 (ERHA53_17720) 1897269..1898876 - 1608 WP_212815994.1 methyl-accepting chemotaxis protein -
KJS81_RS08965 (ERHA53_17730) 1899260..1899541 + 282 WP_133843476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KJS81_RS08970 (ERHA53_17740) 1899541..1899858 + 318 WP_133843073.1 HigA family addiction module antitoxin Antitoxin
KJS81_RS08975 (ERHA53_17750) 1899930..1901204 - 1275 WP_159337011.1 enterobactin transporter EntS -
KJS81_RS08980 (ERHA53_17770) 1901376..1902401 + 1026 WP_133843077.1 Fe(3+)-siderophore ABC transporter permease -
KJS81_RS08985 (ERHA53_17780) 1902412..1903446 + 1035 WP_133843079.1 iron-enterobactin ABC transporter permease -
KJS81_RS08990 (ERHA53_17790) 1903449..1904270 + 822 WP_133843081.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11029.53 Da        Isoelectric Point: 9.3752

>T38373 WP_133843476.1 NZ_AP024329:1899260-1899541 [Erwinia rhapontici]
VIKSWKHKGLQKLFETGNPSGVQAKDAERIRTRLLVLDEALSVEEFRNYPGFRFHPLKGDRQYLYAITVRANWRITFEFR
DGDAYILNLEDYH

Download         Length: 282 bp

>T38373 NZ_AP024329:1899260-1899541 [Erwinia rhapontici]
GTGATCAAAAGCTGGAAGCATAAGGGATTGCAAAAACTGTTCGAAACAGGAAATCCCAGTGGTGTGCAGGCCAAAGATGC
CGAACGGATCAGAACGCGTCTGCTGGTTCTTGACGAAGCCCTGTCGGTAGAAGAATTCAGAAACTACCCTGGCTTCAGGT
TCCATCCGCTGAAAGGCGACAGGCAGTATCTTTACGCCATTACTGTTCGTGCCAACTGGCGTATCACTTTCGAGTTCAGA
GACGGTGATGCTTACATACTTAATCTGGAGGACTACCACTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11153.84 Da        Isoelectric Point: 4.6854

>AT38373 WP_133843073.1 NZ_AP024329:1899541-1899858 [Erwinia rhapontici]
MAMMTPPHPGSLITEYLEDYNVSLRTLAGNLGVSPSALSKAAAGKTAITPEMAVRLEAGLGIAARLWLAMQATYDISRVR
ETIDITQVVPACYDETDGQPVKTCG

Download         Length: 318 bp

>AT38373 NZ_AP024329:1899541-1899858 [Erwinia rhapontici]
ATGGCTATGATGACCCCCCCGCATCCGGGCAGCCTGATTACCGAGTATCTTGAGGACTATAACGTCAGCCTGCGGACGCT
GGCCGGAAACCTCGGGGTATCCCCCTCGGCGTTGAGCAAAGCGGCGGCAGGAAAAACCGCTATTACCCCTGAAATGGCGG
TACGGCTGGAAGCCGGGCTGGGCATTGCGGCCCGTCTCTGGCTGGCGATGCAGGCAACGTACGATATTAGCCGGGTCCGC
GAAACGATTGATATCACGCAGGTCGTGCCCGCCTGCTATGACGAAACCGATGGTCAGCCAGTGAAGACCTGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References