38368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1008619..1009133 Replicon chromosome
Accession NZ_AP024320
Organism Limosilactobacillus fermentum strain ike38

Toxin (Protein)


Gene name yoeB Uniprot ID C0WV68
Locus tag ikematsu_RS05005 Protein ID WP_003684072.1
Coordinates 1008870..1009133 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag ikematsu_RS05000 Protein ID WP_003684069.1
Coordinates 1008619..1008873 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ikematsu_RS04970 1004291..1004578 + 288 WP_003688751.1 transposase -
ikematsu_RS04975 1004602..1005495 + 894 WP_204022136.1 IS3 family transposase -
ikematsu_RS04980 1005620..1006384 - 765 WP_080650602.1 zinc ribbon domain-containing protein -
ikematsu_RS04985 1006405..1006866 - 462 WP_204022139.1 hypothetical protein -
ikematsu_RS04990 1007181..1008059 - 879 WP_012391422.1 IS3 family transposase -
ikematsu_RS04995 1008083..1008370 - 288 WP_003688751.1 transposase -
ikematsu_RS05000 1008619..1008873 + 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ikematsu_RS05005 1008870..1009133 + 264 WP_003684072.1 Txe/YoeB family addiction module toxin Toxin
ikematsu_RS05010 1009543..1010664 - 1122 WP_123472013.1 PTS sugar transporter subunit IIC -
ikematsu_RS05015 1011152..1011871 - 720 WP_069775720.1 hypothetical protein -
ikematsu_RS05020 1012732..1013772 + 1041 WP_123472452.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10301.03 Da        Isoelectric Point: 10.3799

>T38368 WP_003684072.1 NZ_AP024320:1008870-1009133 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHYE

Download         Length: 264 bp

>T38368 NZ_AP024320:1008870-1009133 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACTGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATTACGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT38368 WP_003684069.1 NZ_AP024320:1008619-1008873 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT38368 NZ_AP024320:1008619-1008873 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGATAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0WV68

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References