Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2150289..2150506 Replicon chromosome
Accession NZ_AP024318
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag K5606_RS10575 Protein ID WP_001802298.1
Coordinates 2150402..2150506 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2150289..2150344 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5606_RS10555 2146428..2147093 - 666 WP_001024099.1 SDR family oxidoreductase -
K5606_RS10560 2147245..2147565 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
K5606_RS10565 2147567..2148547 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
K5606_RS10570 2148813..2149904 + 1092 WP_000495673.1 hypothetical protein -
- 2150289..2150344 + 56 - - Antitoxin
K5606_RS10575 2150402..2150506 - 105 WP_001802298.1 hypothetical protein Toxin
K5606_RS10580 2151186..2151344 + 159 WP_001792784.1 hypothetical protein -
K5606_RS10585 2151780..2151872 + 93 WP_000220902.1 hypothetical protein -
K5606_RS10590 2152002..2152859 - 858 WP_000370942.1 HAD family hydrolase -
K5606_RS10595 2152927..2153709 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
K5606_RS10600 2153999..2154607 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T38364 WP_001802298.1 NZ_AP024318:c2150506-2150402 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T38364 NZ_AP024318:c2150506-2150402 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT38364 NZ_AP024318:2150289-2150344 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References