Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1999664..2000087 Replicon chromosome
Accession NZ_AP024318
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5606_RS09770 Protein ID WP_001836226.1
Coordinates 1999836..2000087 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5606_RS09765 Protein ID WP_000028421.1
Coordinates 1999664..1999846 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5606_RS09720 (1995902) 1995902..1996246 - 345 WP_000402904.1 hypothetical protein -
K5606_RS09725 (1996376) 1996376..1996675 - 300 WP_000988330.1 HNH endonuclease -
K5606_RS09730 (1996907) 1996907..1997323 - 417 WP_000590122.1 hypothetical protein -
K5606_RS09735 (1997351) 1997351..1997551 - 201 WP_103146217.1 DUF1514 family protein -
K5606_RS09740 (1997551) 1997551..1998201 - 651 WP_001005262.1 hypothetical protein -
K5606_RS09745 (1998360) 1998360..1998509 - 150 WP_070030217.1 transcriptional regulator -
K5606_RS09750 (1998522) 1998522..1998980 - 459 WP_031768021.1 hypothetical protein -
K5606_RS09755 (1998973) 1998973..1999125 - 153 WP_031768020.1 DUF1381 domain-containing protein -
K5606_RS09760 (1999162) 1999162..1999671 - 510 WP_031866561.1 dUTP pyrophosphatase -
K5606_RS09765 (1999664) 1999664..1999846 - 183 WP_000028421.1 hypothetical protein Antitoxin
K5606_RS09770 (1999836) 1999836..2000087 - 252 WP_001836226.1 DUF1024 family protein Toxin
K5606_RS09775 (2000080) 2000080..2000451 - 372 WP_001557190.1 hypothetical protein -
K5606_RS09780 (2000460) 2000460..2000702 - 243 WP_000131379.1 phi PVL orf 51-like protein -
K5606_RS09785 (2000706) 2000706..2001074 - 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
K5606_RS09790 (2001087) 2001087..2001491 - 405 WP_103146216.1 RusA family crossover junction endodeoxyribonuclease -
K5606_RS09795 (2001500) 2001500..2001718 - 219 WP_053819389.1 hypothetical protein -
K5606_RS09800 (2001725) 2001725..2002609 - 885 WP_103146215.1 DnaD domain protein -
K5606_RS09805 (2002639) 2002639..2003109 - 471 WP_017466775.1 single-stranded DNA-binding protein -
K5606_RS09810 (2003110) 2003110..2003727 - 618 WP_224211742.1 MBL fold metallo-hydrolase -
K5606_RS09815 (2003808) 2003808..2004728 - 921 WP_103146214.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 1972420..2024841 52421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T38361 WP_001836226.1 NZ_AP024318:c2000087-1999836 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T38361 NZ_AP024318:c2000087-1999836 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT38361 WP_000028421.1 NZ_AP024318:c1999846-1999664 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT38361 NZ_AP024318:c1999846-1999664 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References