Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF1/- |
| Location | 1976768..1977075 | Replicon | chromosome |
| Accession | NZ_AP024318 | ||
| Organism | Staphylococcus aureus strain S36 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | K5606_RS09620 | Protein ID | WP_011447039.1 |
| Coordinates | 1976899..1977075 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF1 | ||
| Locus tag | - | ||
| Coordinates | 1976768..1976907 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5606_RS09580 (1972107) | 1972107..1972367 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| K5606_RS09585 (1972420) | 1972420..1972770 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| K5606_RS09590 (1973455) | 1973455..1973904 | + | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| K5606_RS09595 (1973999) | 1973999..1974334 | - | 336 | Protein_1861 | SH3 domain-containing protein | - |
| K5606_RS09600 (1974984) | 1974984..1975475 | - | 492 | WP_000919350.1 | staphylokinase | - |
| K5606_RS09605 (1975666) | 1975666..1976421 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| K5606_RS09610 (1976433) | 1976433..1976687 | - | 255 | WP_000611512.1 | phage holin | - |
| K5606_RS09615 (1976739) | 1976739..1976846 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - (1976768) | 1976768..1976907 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (1976768) | 1976768..1976907 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (1976768) | 1976768..1976907 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (1976768) | 1976768..1976907 | + | 140 | NuclAT_0 | - | Antitoxin |
| K5606_RS09620 (1976899) | 1976899..1977075 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| K5606_RS09625 (1977225) | 1977225..1977521 | - | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| K5606_RS09630 (1977579) | 1977579..1977866 | - | 288 | WP_001040261.1 | hypothetical protein | - |
| K5606_RS09635 (1977913) | 1977913..1978065 | - | 153 | WP_001153681.1 | hypothetical protein | - |
| K5606_RS09640 (1978055) | 1978055..1981840 | - | 3786 | WP_000582165.1 | phage tail spike protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / hlb / groEL | 1972420..2024841 | 52421 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T38358 WP_011447039.1 NZ_AP024318:c1977075-1976899 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T38358 NZ_AP024318:c1977075-1976899 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT38358 NZ_AP024318:1976768-1976907 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
