Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2031888..2032311 Replicon chromosome
Accession NZ_AP024315
Organism Staphylococcus aureus strain BDH17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5602_RS09905 Protein ID WP_001836226.1
Coordinates 2032060..2032311 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5602_RS09900 Protein ID WP_000028421.1
Coordinates 2031888..2032070 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5602_RS09855 (2028126) 2028126..2028470 - 345 WP_000402904.1 hypothetical protein -
K5602_RS09860 (2028600) 2028600..2028899 - 300 WP_000988330.1 HNH endonuclease -
K5602_RS09865 (2029131) 2029131..2029547 - 417 WP_000590122.1 hypothetical protein -
K5602_RS09870 (2029575) 2029575..2029775 - 201 WP_103146217.1 DUF1514 family protein -
K5602_RS09875 (2029775) 2029775..2030425 - 651 WP_001005262.1 hypothetical protein -
K5602_RS09880 (2030584) 2030584..2030733 - 150 WP_070030217.1 transcriptional regulator -
K5602_RS09885 (2030746) 2030746..2031204 - 459 WP_031768021.1 hypothetical protein -
K5602_RS09890 (2031197) 2031197..2031349 - 153 WP_031768020.1 DUF1381 domain-containing protein -
K5602_RS09895 (2031386) 2031386..2031895 - 510 WP_031866561.1 dUTP pyrophosphatase -
K5602_RS09900 (2031888) 2031888..2032070 - 183 WP_000028421.1 hypothetical protein Antitoxin
K5602_RS09905 (2032060) 2032060..2032311 - 252 WP_001836226.1 DUF1024 family protein Toxin
K5602_RS09910 (2032304) 2032304..2032675 - 372 WP_001557190.1 hypothetical protein -
K5602_RS09915 (2032684) 2032684..2032926 - 243 WP_000131379.1 phi PVL orf 51-like protein -
K5602_RS09920 (2032930) 2032930..2033298 - 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
K5602_RS09925 (2033311) 2033311..2033715 - 405 WP_103146216.1 RusA family crossover junction endodeoxyribonuclease -
K5602_RS09930 (2033724) 2033724..2033942 - 219 WP_053819389.1 hypothetical protein -
K5602_RS09935 (2033949) 2033949..2034833 - 885 WP_103146215.1 DnaD domain protein -
K5602_RS09940 (2034863) 2034863..2035333 - 471 WP_017466775.1 single-stranded DNA-binding protein -
K5602_RS09945 (2035334) 2035334..2035951 - 618 WP_224211742.1 MBL fold metallo-hydrolase -
K5602_RS09950 (2036032) 2036032..2036952 - 921 WP_103146214.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2004044..2057065 53021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T38349 WP_001836226.1 NZ_AP024315:c2032311-2032060 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T38349 NZ_AP024315:c2032311-2032060 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT38349 WP_000028421.1 NZ_AP024315:c2032070-2031888 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT38349 NZ_AP024315:c2032070-2031888 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References