Detailed information of TA system TA038346

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2008992..2009299
• Replicon: chromosome
• Accession: NZ_AP024315
• Organism: Staphylococcus aureus strain BDH17

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K5602_RS09755
• Protein ID: WP_011447039.1
• Coordinates: 2009123..2009299 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2008992..2009131 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5602_RS09715 (2004331)	2004331..2004591	+	261	WP_001791826.1	hypothetical protein	-
K5602_RS09720 (2004644)	2004644..2004994	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K5602_RS09725 (2005679)	2005679..2006128	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K5602_RS09730 (2006223)	2006223..2006558	-	336	Protein_1888	SH3 domain-containing protein	-
K5602_RS09735 (2007208)	2007208..2007699	-	492	WP_000919350.1	staphylokinase	-
K5602_RS09740 (2007890)	2007890..2008645	-	756	WP_000861038.1	CHAP domain-containing protein	-
K5602_RS09745 (2008657)	2008657..2008911	-	255	WP_221062108.1	phage holin	-
K5602_RS09750 (2008963)	2008963..2009070	+	108	WP_001791821.1	hypothetical protein	-
- (2008992)	2008992..2009131	+	140	NuclAT_0	-	Antitoxin
- (2008992)	2008992..2009131	+	140	NuclAT_0	-	Antitoxin
- (2008992)	2008992..2009131	+	140	NuclAT_0	-	Antitoxin
- (2008992)	2008992..2009131	+	140	NuclAT_0	-	Antitoxin
K5602_RS09755 (2009123)	2009123..2009299	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K5602_RS09760 (2009449)	2009449..2009745	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
K5602_RS09765 (2009803)	2009803..2010090	-	288	WP_001040261.1	hypothetical protein	-
K5602_RS09770 (2010137)	2010137..2010289	-	153	WP_001153681.1	hypothetical protein	-
K5602_RS09775 (2010279)	2010279..2014064	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2004044..2057065	53021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38346 WP_011447039.1 NZ_AP024315:c2009299-2009123 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38346 NZ_AP024315:c2009299-2009123 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT38346 NZ_AP024315:2008992-2009131 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin