Detailed information of TA system TA038342

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2540233..2540417
• Replicon: chromosome
• Accession: NZ_AP024313
• Organism: Staphylococcus aureus strain N1195

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: K5605_RS12670
• Protein ID: WP_000482647.1
• Coordinates: 2540310..2540417 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2540233..2540293 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5605_RS12655	2535687..2535854	-	168	WP_001798790.1	hypothetical protein	-
K5605_RS12660	2536085..2537818	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
K5605_RS12665	2537843..2539606	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2540233..2540293	+	61	-	-	Antitoxin
K5605_RS12670	2540310..2540417	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
K5605_RS12675	2540551..2540937	-	387	WP_000779355.1	flippase GtxA	-
K5605_RS12680	2541204..2542346	+	1143	WP_001176859.1	glycerate kinase	-
K5605_RS12685	2542406..2543065	+	660	WP_000831300.1	hypothetical protein	-
K5605_RS12690	2543253..2544464	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
K5605_RS12695	2544587..2545060	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T38342 WP_000482647.1 NZ_AP024313:c2540417-2540310 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T38342 NZ_AP024313:c2540417-2540310 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT38342 NZ_AP024313:2540233-2540293 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin