Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2092724..2093147 Replicon chromosome
Accession NZ_AP024313
Organism Staphylococcus aureus strain N1195

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5605_RS10325 Protein ID WP_001836226.1
Coordinates 2092896..2093147 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5605_RS10320 Protein ID WP_000028421.1
Coordinates 2092724..2092906 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5605_RS10275 (2088962) 2088962..2089306 - 345 WP_000402904.1 hypothetical protein -
K5605_RS10280 (2089436) 2089436..2089735 - 300 WP_000988330.1 HNH endonuclease -
K5605_RS10285 (2089967) 2089967..2090383 - 417 WP_000590122.1 hypothetical protein -
K5605_RS10290 (2090411) 2090411..2090611 - 201 WP_103146217.1 DUF1514 family protein -
K5605_RS10295 (2090611) 2090611..2091261 - 651 WP_001005262.1 hypothetical protein -
K5605_RS10300 (2091420) 2091420..2091569 - 150 WP_070030217.1 transcriptional regulator -
K5605_RS10305 (2091582) 2091582..2092040 - 459 WP_031768021.1 hypothetical protein -
K5605_RS10310 (2092033) 2092033..2092185 - 153 WP_031768020.1 DUF1381 domain-containing protein -
K5605_RS10315 (2092222) 2092222..2092731 - 510 WP_031866561.1 dUTP pyrophosphatase -
K5605_RS10320 (2092724) 2092724..2092906 - 183 WP_000028421.1 hypothetical protein Antitoxin
K5605_RS10325 (2092896) 2092896..2093147 - 252 WP_001836226.1 DUF1024 family protein Toxin
K5605_RS10330 (2093140) 2093140..2093511 - 372 WP_001557190.1 hypothetical protein -
K5605_RS10335 (2093520) 2093520..2093762 - 243 WP_000131379.1 phi PVL orf 51-like protein -
K5605_RS10340 (2093766) 2093766..2094134 - 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
K5605_RS10345 (2094147) 2094147..2094551 - 405 WP_103146216.1 RusA family crossover junction endodeoxyribonuclease -
K5605_RS10350 (2094560) 2094560..2094778 - 219 WP_053819389.1 hypothetical protein -
K5605_RS10355 (2094785) 2094785..2095669 - 885 WP_103146215.1 DnaD domain protein -
K5605_RS10360 (2095699) 2095699..2096169 - 471 WP_017466775.1 single-stranded DNA-binding protein -
K5605_RS10365 (2096170) 2096170..2096787 - 618 WP_224211742.1 MBL fold metallo-hydrolase -
K5605_RS10370 (2096868) 2096868..2097788 - 921 WP_103146214.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2065480..2117901 52421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T38337 WP_001836226.1 NZ_AP024313:c2093147-2092896 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T38337 NZ_AP024313:c2093147-2092896 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT38337 WP_000028421.1 NZ_AP024313:c2092906-2092724 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT38337 NZ_AP024313:c2092906-2092724 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References