Detailed information of TA system TA038334

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2069828..2070135
• Replicon: chromosome
• Accession: NZ_AP024313
• Organism: Staphylococcus aureus strain N1195

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K5605_RS10180
• Protein ID: WP_011447039.1
• Coordinates: 2069959..2070135 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2069828..2069967 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5605_RS10140 (2065167)	2065167..2065427	+	261	WP_001791826.1	hypothetical protein	-
K5605_RS10145 (2065480)	2065480..2065830	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K5605_RS10150 (2066515)	2066515..2066964	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K5605_RS10155 (2067059)	2067059..2067394	-	336	Protein_1975	SH3 domain-containing protein	-
K5605_RS10160 (2068044)	2068044..2068535	-	492	WP_000919350.1	staphylokinase	-
K5605_RS10165 (2068726)	2068726..2069481	-	756	WP_000861038.1	CHAP domain-containing protein	-
K5605_RS10170 (2069493)	2069493..2069747	-	255	WP_000611512.1	phage holin	-
K5605_RS10175 (2069799)	2069799..2069906	+	108	WP_001791821.1	hypothetical protein	-
- (2069828)	2069828..2069967	+	140	NuclAT_0	-	Antitoxin
- (2069828)	2069828..2069967	+	140	NuclAT_0	-	Antitoxin
- (2069828)	2069828..2069967	+	140	NuclAT_0	-	Antitoxin
- (2069828)	2069828..2069967	+	140	NuclAT_0	-	Antitoxin
K5605_RS10180 (2069959)	2069959..2070135	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K5605_RS10185 (2070285)	2070285..2070581	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
K5605_RS10190 (2070639)	2070639..2070926	-	288	WP_001040261.1	hypothetical protein	-
K5605_RS10195 (2070973)	2070973..2071125	-	153	WP_001153681.1	hypothetical protein	-
K5605_RS10200 (2071115)	2071115..2074900	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2065480..2117901	52421

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38334 WP_011447039.1 NZ_AP024313:c2070135-2069959 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38334 NZ_AP024313:c2070135-2069959 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT38334 NZ_AP024313:2069828-2069967 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin