Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2544211..2544395 Replicon chromosome
Accession NZ_AP024311
Organism Staphylococcus aureus strain THI2018-120

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag ST1232TP_RS12695 Protein ID WP_000482647.1
Coordinates 2544288..2544395 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2544211..2544271 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ST1232TP_RS12680 2539665..2539832 - 168 WP_001798790.1 hypothetical protein -
ST1232TP_RS12685 2540063..2541796 - 1734 WP_000486511.1 ABC transporter ATP-binding protein -
ST1232TP_RS12690 2541821..2543584 - 1764 WP_001064818.1 ABC transporter ATP-binding protein -
- 2544211..2544271 + 61 - - Antitoxin
ST1232TP_RS12695 2544288..2544395 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
ST1232TP_RS12700 2544529..2544915 - 387 WP_000779355.1 flippase GtxA -
ST1232TP_RS12705 2545182..2546324 + 1143 WP_001176859.1 glycerate kinase -
ST1232TP_RS12710 2546384..2547043 + 660 WP_000831300.1 hypothetical protein -
ST1232TP_RS12715 2547231..2548442 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
ST1232TP_RS12720 2548565..2549038 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T38330 WP_000482647.1 NZ_AP024311:c2544395-2544288 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T38330 NZ_AP024311:c2544395-2544288 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT38330 NZ_AP024311:2544211-2544271 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References