Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2095370..2095793 | Replicon | chromosome |
| Accession | NZ_AP024311 | ||
| Organism | Staphylococcus aureus strain THI2018-120 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | ST1232TP_RS10340 | Protein ID | WP_001836226.1 |
| Coordinates | 2095542..2095793 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | ST1232TP_RS10335 | Protein ID | WP_000028421.1 |
| Coordinates | 2095370..2095552 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ST1232TP_RS10290 (2091608) | 2091608..2091952 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| ST1232TP_RS10295 (2092082) | 2092082..2092381 | - | 300 | WP_000988330.1 | HNH endonuclease | - |
| ST1232TP_RS10300 (2092613) | 2092613..2093029 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| ST1232TP_RS10305 (2093057) | 2093057..2093257 | - | 201 | WP_103146217.1 | DUF1514 family protein | - |
| ST1232TP_RS10310 (2093257) | 2093257..2093907 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| ST1232TP_RS10315 (2094066) | 2094066..2094215 | - | 150 | WP_070030217.1 | transcriptional regulator | - |
| ST1232TP_RS10320 (2094228) | 2094228..2094686 | - | 459 | WP_031768021.1 | hypothetical protein | - |
| ST1232TP_RS10325 (2094679) | 2094679..2094831 | - | 153 | WP_031768020.1 | DUF1381 domain-containing protein | - |
| ST1232TP_RS10330 (2094868) | 2094868..2095377 | - | 510 | WP_031866561.1 | dUTP pyrophosphatase | - |
| ST1232TP_RS10335 (2095370) | 2095370..2095552 | - | 183 | WP_000028421.1 | hypothetical protein | Antitoxin |
| ST1232TP_RS10340 (2095542) | 2095542..2095793 | - | 252 | WP_001836226.1 | DUF1024 family protein | Toxin |
| ST1232TP_RS10345 (2095786) | 2095786..2096157 | - | 372 | WP_001557190.1 | hypothetical protein | - |
| ST1232TP_RS10350 (2096166) | 2096166..2096408 | - | 243 | WP_000131379.1 | phi PVL orf 51-like protein | - |
| ST1232TP_RS10355 (2096412) | 2096412..2096780 | - | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| ST1232TP_RS10360 (2096793) | 2096793..2097197 | - | 405 | WP_103146216.1 | RusA family crossover junction endodeoxyribonuclease | - |
| ST1232TP_RS10365 (2097206) | 2097206..2097424 | - | 219 | WP_053819389.1 | hypothetical protein | - |
| ST1232TP_RS10370 (2097431) | 2097431..2098315 | - | 885 | WP_103146215.1 | DnaD domain protein | - |
| ST1232TP_RS10375 (2098345) | 2098345..2098815 | - | 471 | WP_017466775.1 | single-stranded DNA-binding protein | - |
| ST1232TP_RS10380 (2098816) | 2098816..2099433 | - | 618 | WP_224211742.1 | MBL fold metallo-hydrolase | - |
| ST1232TP_RS10385 (2099514) | 2099514..2100434 | - | 921 | WP_103146214.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / hlb / groEL | 2068126..2124877 | 56751 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9457.35 Da Isoelectric Point: 3.8049
>T38325 WP_001836226.1 NZ_AP024311:c2095793-2095542 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T38325 NZ_AP024311:c2095793-2095542 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG
Antitoxin
Download Length: 61 a.a. Molecular weight: 6683.59 Da Isoelectric Point: 4.3791
>AT38325 WP_000028421.1 NZ_AP024311:c2095552-2095370 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
Download Length: 183 bp
>AT38325 NZ_AP024311:c2095552-2095370 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|