Detailed information of TA system TA038322

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2072474..2072781
• Replicon: chromosome
• Accession: NZ_AP024311
• Organism: Staphylococcus aureus strain THI2018-120

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ST1232TP_RS10195
• Protein ID: WP_011447039.1
• Coordinates: 2072605..2072781 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2072474..2072613 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ST1232TP_RS10155 (2067813)	2067813..2068073	+	261	WP_001791826.1	hypothetical protein	-
ST1232TP_RS10160 (2068126)	2068126..2068476	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ST1232TP_RS10165 (2069161)	2069161..2069610	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ST1232TP_RS10170 (2069705)	2069705..2070040	-	336	Protein_1978	SH3 domain-containing protein	-
ST1232TP_RS10175 (2070690)	2070690..2071181	-	492	WP_000919350.1	staphylokinase	-
ST1232TP_RS10180 (2071372)	2071372..2072127	-	756	WP_000861038.1	CHAP domain-containing protein	-
ST1232TP_RS10185 (2072139)	2072139..2072393	-	255	WP_000611512.1	phage holin	-
ST1232TP_RS10190 (2072445)	2072445..2072552	+	108	WP_001791821.1	hypothetical protein	-
- (2072474)	2072474..2072613	+	140	NuclAT_0	-	Antitoxin
- (2072474)	2072474..2072613	+	140	NuclAT_0	-	Antitoxin
- (2072474)	2072474..2072613	+	140	NuclAT_0	-	Antitoxin
- (2072474)	2072474..2072613	+	140	NuclAT_0	-	Antitoxin
ST1232TP_RS10195 (2072605)	2072605..2072781	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
ST1232TP_RS10200 (2072931)	2072931..2073227	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
ST1232TP_RS10205 (2073285)	2073285..2073572	-	288	WP_001040261.1	hypothetical protein	-
ST1232TP_RS10210 (2073619)	2073619..2073771	-	153	WP_001153681.1	hypothetical protein	-
ST1232TP_RS10215 (2073761)	2073761..2077546	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2068126..2124877	56751

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38322 WP_011447039.1 NZ_AP024311:c2072781-2072605 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38322 NZ_AP024311:c2072781-2072605 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTACAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT38322 NZ_AP024311:2072474-2072613 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin