Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 743846..744291 Replicon chromosome
Accession NZ_AP024308
Organism Cutibacterium avidum strain TP-CV4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag TPCV4_RS03425 Protein ID WP_221268889.1
Coordinates 743846..744064 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TPCV4_RS03430 Protein ID WP_260186280.1
Coordinates 744115..744291 (+) Length 59 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TPCV4_RS03405 (TPCV4_06860) 739190..739816 + 627 WP_249361230.1 hypothetical protein -
TPCV4_RS03410 (TPCV4_06870) 739881..740930 + 1050 WP_065674110.1 YdcF family protein -
TPCV4_RS03415 (TPCV4_06890) 741173..741580 + 408 WP_065674109.1 DUF4232 domain-containing protein -
TPCV4_RS03420 (TPCV4_06900) 742846..743442 + 597 WP_065674108.1 hypothetical protein -
TPCV4_RS03425 (TPCV4_06910) 743846..744064 + 219 WP_221268889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TPCV4_RS03430 (TPCV4_06920) 744115..744291 + 177 WP_260186280.1 HigA family addiction module antitoxin Antitoxin
TPCV4_RS03435 (TPCV4_06940) 745205..746626 - 1422 WP_065674107.1 type I glutamate--ammonia ligase -
TPCV4_RS03440 (TPCV4_06950) 746739..747161 + 423 WP_065674106.1 RDD family protein -
TPCV4_RS03445 (TPCV4_06960) 747167..748279 + 1113 WP_036975842.1 glycosyltransferase -
TPCV4_RS03450 (TPCV4_06970) 748303..748911 + 609 WP_065674105.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-72)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-58)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8234.43 Da        Isoelectric Point: 10.6671

>T38315 WP_221268889.1 NZ_AP024308:743846-744064 [Cutibacterium avidum]
VIRSFGSTDTERVWHRERVPSMDPRILRVALRKLRQVGSAEMLEDLCVPPGNRLEALKGDRAGQHSIRINDQ

Download         Length: 219 bp

>T38315 NZ_AP024308:743846-744064 [Cutibacterium avidum]
GTGATCAGATCGTTCGGGAGCACGGACACCGAGCGGGTGTGGCATCGTGAGCGTGTGCCCTCCATGGATCCCCGGATCCT
CCGGGTGGCATTGCGCAAGCTTCGTCAGGTGGGATCTGCGGAGATGCTCGAGGACCTCTGCGTTCCACCCGGTAACCGAC
TCGAGGCGCTCAAGGGCGACCGAGCTGGTCAGCACAGCATCAGAATCAATGACCAGTGA

Antitoxin


Download         Length: 59 a.a.        Molecular weight: 6318.14 Da        Isoelectric Point: 4.5980

>AT38315 WP_260186280.1 NZ_AP024308:744115-744291 [Cutibacterium avidum]
MTTTDEIESIHPGEVLMEDFIEGFGVTQHNLAVSIGVPSRRINEIVHGKRGISVDTAL

Download         Length: 177 bp

>AT38315 NZ_AP024308:744115-744291 [Cutibacterium avidum]
TTGACTACTACTGACGAGATCGAGTCGATCCATCCGGGAGAAGTTCTCATGGAGGATTTCATCGAGGGGTTCGGGGTCAC
GCAGCACAATCTCGCTGTGTCGATAGGTGTGCCGTCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGAGGGATCTCAG
TGGACACCGCATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References