Detailed information of TA system TA038183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3492804..3493396
• Replicon: chromosome
• Accession: NZ_AP024239
• Organism: Thiohalobacter sp. COW1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: COW1_RS16585
• Protein ID: WP_096366942.1
• Coordinates: 3492804..3493085 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: COW1_RS16590
• Protein ID: WP_096367609.1
• Coordinates: 3493097..3493396 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COW1_RS16555	3488527..3488790	+	264	WP_201344854.1	hypothetical protein	-
COW1_RS16560	3488893..3489333	+	441	WP_201344856.1	hypothetical protein	-
COW1_RS16565	3489439..3490221	+	783	WP_201344858.1	hypothetical protein	-
COW1_RS16570	3490253..3490903	+	651	WP_096366945.1	DUF4145 domain-containing protein	-
COW1_RS16575	3490976..3492165	+	1190	WP_201344860.1	IS3 family transposase	-
COW1_RS16580	3492275..3492634	+	360	WP_157745665.1	hypothetical protein	-
COW1_RS16585	3492804..3493085	+	282	WP_096366942.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
COW1_RS16590	3493097..3493396	+	300	WP_096367609.1	HigA family addiction module antidote protein	Antitoxin
COW1_RS16595	3493480..3493797	+	318	WP_096366941.1	multidrug efflux SMR transporter	-
COW1_RS16600	3493896..3494219	+	324	WP_201344862.1	helix-hairpin-helix domain-containing protein	-
COW1_RS16605	3494474..3495013	+	540	WP_201344864.1	PEP-CTERM sorting domain-containing protein	-
COW1_RS16610	3495223..3495498	+	276	WP_201344866.1	PhzF family phenazine biosynthesis protein	-
COW1_RS16615	3495826..3496218	+	393	WP_201344868.1	hypothetical protein	-
COW1_RS16620	3496331..3496966	+	636	WP_201344870.1	LysE family translocator	-
COW1_RS16625	3497021..3497263	+	243	WP_201344872.1	DUF4282 domain-containing protein	-
COW1_RS16630	3497278..3498189	-	912	WP_201344874.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	3487165..3493461	6296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10792.55 Da
• Isoelectric Point: 10.1313

>T38183 WP_096366942.1 NZ_AP024239:3492804-3493085 [Thiohalobacter sp. COW1]
MIKSFKGKEAEKIYQGCYSKRIPKDIQRLAARKLEMLAAASDLKSLRIPPSNRLEKLKGDRAGQYSIRINDQWRICFIWK
AGDAHEVDIVDYH

Nucleotide

• Length: 282 bp

>T38183 NZ_AP024239:3492804-3493085 [Thiohalobacter sp. COW1]
ATGATCAAATCGTTCAAGGGCAAGGAAGCTGAGAAGATTTATCAGGGGTGCTATTCGAAGCGGATTCCCAAAGACATTCA
ACGCCTTGCGGCACGGAAACTGGAAATGCTCGCTGCGGCGAGCGATCTCAAATCATTGAGAATTCCACCGTCCAACCGTC
TTGAAAAACTGAAGGGTGACAGGGCAGGTCAATACAGTATACGAATCAACGATCAATGGCGTATCTGCTTTATCTGGAAA
GCCGGTGATGCTCATGAGGTGGATATCGTTGATTATCATTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11378.12 Da
• Isoelectric Point: 8.0293

>AT38183 WP_096367609.1 NZ_AP024239:3493097-3493396 [Thiohalobacter sp. COW1]
MAKRDFDPIHPGEILLEEFLRPMGISQYRLAKDISVAQRRISEITQGKRSITADTALRLGRYFGMEAQFWLNLQSRYDLL
CAEAELAKRLDKEVTPHAA

Nucleotide

• Length: 300 bp

>AT38183 NZ_AP024239:3493097-3493396 [Thiohalobacter sp. COW1]
ATGGCTAAGAGAGATTTCGATCCCATTCATCCTGGTGAAATTCTGCTTGAGGAATTCTTGCGGCCCATGGGTATATCTCA
ATACCGCCTTGCAAAAGATATCAGTGTGGCGCAACGCCGTATAAGCGAAATTACCCAAGGCAAGCGGTCTATTACAGCTG
ATACGGCGTTGCGCCTCGGTCGGTACTTTGGCATGGAGGCGCAGTTTTGGCTCAATCTTCAGTCGCGTTACGATCTTTTG
TGTGCAGAAGCGGAGCTCGCCAAACGGCTGGACAAAGAAGTTACGCCCCATGCGGCATAG