Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1523207..1523811 Replicon chromosome
Accession NZ_AP024239
Organism Thiohalobacter sp. COW1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COW1_RS07145 Protein ID WP_201346055.1
Coordinates 1523518..1523811 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COW1_RS07140 Protein ID WP_201345877.1
Coordinates 1523207..1523509 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COW1_RS07110 1518741..1519118 - 378 WP_201345872.1 hypothetical protein -
COW1_RS07115 1519592..1520365 - 774 WP_201345873.1 hypothetical protein -
COW1_RS07120 1520359..1521438 - 1080 WP_201345874.1 hypothetical protein -
COW1_RS07125 1521460..1521798 - 339 WP_201346054.1 HNH endonuclease -
COW1_RS07130 1521903..1522655 - 753 WP_201345875.1 hypothetical protein -
COW1_RS07135 1522746..1523027 - 282 WP_201345876.1 hypothetical protein -
COW1_RS07140 1523207..1523509 - 303 WP_201345877.1 HigA family addiction module antidote protein Antitoxin
COW1_RS07145 1523518..1523811 - 294 WP_201346055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COW1_RS07150 1524229..1525806 - 1578 WP_096365761.1 glutamine-hydrolyzing GMP synthase -
COW1_RS07155 1526043..1527506 - 1464 WP_197703044.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1476437..1523814 47377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-83)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11695.12 Da        Isoelectric Point: 8.0443

>T38182 WP_201346055.1 NZ_AP024239:c1523811-1523518 [Thiohalobacter sp. COW1]
IQSFRDRWLRDYYLEDKTSKKIPAEVEDRLFRKLQLIDDATCDLDLRSPPSNHFEKLRGNLAGKHSIRVNKQWRLVFTWS
GERGEAQDIYLDNHDYR

Download         Length: 294 bp

>T38182 NZ_AP024239:c1523811-1523518 [Thiohalobacter sp. COW1]
ATTCAGAGTTTTCGGGACCGCTGGCTAAGGGATTATTATCTGGAAGATAAAACCAGCAAGAAGATACCCGCTGAGGTCGA
AGACCGGCTGTTCCGAAAGCTGCAGTTAATCGATGATGCGACCTGTGATCTCGACTTGCGGTCGCCTCCGAGCAATCATT
TTGAAAAGTTGAGAGGAAATTTGGCCGGGAAACATTCGATTCGCGTTAACAAGCAATGGCGGCTGGTGTTTACCTGGTCC
GGCGAACGTGGTGAGGCCCAGGACATCTATCTGGATAACCACGATTATCGGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11100.96 Da        Isoelectric Point: 11.0207

>AT38182 WP_201345877.1 NZ_AP024239:c1523509-1523207 [Thiohalobacter sp. COW1]
MNITKRQPVSVGEMITEEFLVPMALTQGQLAEAMGVSRKTVNELCTNRRAITADTALMLATVFGNSAGFWLNLQQRNDVW
KALNTPKRRARIEKAKPIAA

Download         Length: 303 bp

>AT38182 NZ_AP024239:c1523509-1523207 [Thiohalobacter sp. COW1]
ATGAATATCACAAAACGGCAACCCGTCAGTGTCGGTGAGATGATTACTGAGGAGTTTCTCGTGCCCATGGCGTTGACTCA
GGGGCAACTTGCAGAAGCGATGGGTGTCAGCCGCAAAACCGTCAATGAGTTATGTACCAACCGCCGTGCAATCACGGCTG
ACACGGCACTGATGCTGGCTACTGTATTTGGGAATTCAGCTGGTTTTTGGTTGAATCTGCAGCAACGCAACGACGTGTGG
AAAGCACTCAACACACCAAAACGACGGGCCCGGATCGAGAAGGCTAAGCCGATTGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References