Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 467450..468033 Replicon chromosome
Accession NZ_AP024239
Organism Thiohalobacter sp. COW1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COW1_RS02100 Protein ID WP_201346006.1
Coordinates 467450..467704 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COW1_RS02105 Protein ID WP_096366676.1
Coordinates 467701..468033 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COW1_RS02065 462841..465282 + 2442 WP_096366695.1 AAA family ATPase -
COW1_RS02075 465642..465839 + 198 WP_096366694.1 hypothetical protein -
COW1_RS02085 465997..466374 - 378 WP_201345272.1 type II toxin-antitoxin system VapC family toxin -
COW1_RS02090 466371..466577 - 207 WP_201345273.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
COW1_RS02095 466937..467191 + 255 WP_201345274.1 hypothetical protein -
COW1_RS02100 467450..467704 + 255 WP_201346006.1 toxin higb- component of a toxin-antitoxin loci Toxin
COW1_RS02105 467701..468033 + 333 WP_096366676.1 helix-turn-helix domain-containing protein Antitoxin
COW1_RS02110 468119..468316 + 198 WP_096366675.1 type II toxin-antitoxin system VapB family antitoxin -
COW1_RS02115 468786..470258 + 1473 WP_201345275.1 sensor histidine kinase -
COW1_RS02120 470255..471610 + 1356 WP_201345276.1 sigma-54 dependent transcriptional regulator -
COW1_RS02125 471622..472473 - 852 WP_172844329.1 universal stress protein -
COW1_RS02130 472491..472916 - 426 WP_096366671.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9829.23 Da        Isoelectric Point: 10.2614

>T38181 WP_201346006.1 NZ_AP024239:467450-467704 [Thiohalobacter sp. COW1]
MENPELGDVIPGTGGFRKLRWQDARRGKGKRGGLRVIYYYLTDDGQIWFFALYDKDEAVDLSAEEKRLLKQAIQQELAAR
RRKR

Download         Length: 255 bp

>T38181 NZ_AP024239:467450-467704 [Thiohalobacter sp. COW1]
CTGGAAAATCCGGAACTCGGTGATGTGATTCCCGGGACGGGCGGGTTCCGCAAGTTGCGCTGGCAGGATGCACGCCGGGG
CAAGGGAAAGCGGGGCGGTTTGCGGGTGATTTATTACTATCTCACCGACGATGGTCAGATCTGGTTCTTTGCGCTGTATG
ACAAGGACGAGGCGGTGGATTTAAGTGCCGAGGAAAAACGACTGCTTAAACAGGCGATTCAACAGGAGTTGGCCGCCAGG
AGGCGAAAGCGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12654.55 Da        Isoelectric Point: 10.6370

>AT38181 WP_096366676.1 NZ_AP024239:467701-468033 [Thiohalobacter sp. COW1]
MSRKRKLFDELMEGVDAMRSQREGKITLRTHEVEALPPLEIDPATIRETREKLHVSRAVFARHLRVSTRTLENWEQGRAR
PNAQAAALILMVRQYPDTLEKLHSLNNAAA

Download         Length: 333 bp

>AT38181 NZ_AP024239:467701-468033 [Thiohalobacter sp. COW1]
ATGAGCAGGAAACGCAAGCTGTTTGATGAATTGATGGAAGGGGTGGATGCCATGCGCTCGCAGCGCGAGGGCAAGATCAC
GCTGCGTACCCACGAGGTTGAAGCATTGCCCCCGCTTGAGATCGACCCTGCCACCATTCGGGAGACGCGCGAAAAACTGC
ATGTGTCCCGTGCGGTGTTCGCCCGCCATCTGCGTGTGTCGACCCGAACCCTCGAAAATTGGGAACAAGGCCGCGCCAGG
CCCAATGCCCAGGCGGCGGCTCTGATCCTGATGGTTCGTCAGTACCCGGATACGCTGGAGAAGCTGCACTCGCTAAACAA
TGCCGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References