Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 718315..719008 Replicon chromosome
Accession NZ_AP024205
Organism Escherichia coli strain TA8571

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JG732_RS03480 Protein ID WP_063084548.1
Coordinates 718315..718611 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JG732_RS03485 Protein ID WP_000650107.1
Coordinates 718613..719008 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG732_RS03445 713403..713717 - 315 WP_063084545.1 antibiotic biosynthesis monooxygenase -
JG732_RS03450 713748..714329 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JG732_RS03455 714648..714980 + 333 WP_000917684.1 DUF2645 family protein -
JG732_RS03460 715026..716375 - 1350 WP_063084546.1 two-component system sensor histidine kinase QseC -
JG732_RS03465 716372..717031 - 660 WP_001221493.1 two-component system response regulator QseB -
JG732_RS03470 717183..717575 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JG732_RS03475 717628..718110 + 483 WP_000183505.1 transcriptional regulator -
JG732_RS03480 718315..718611 + 297 WP_063084548.1 type II toxin-antitoxin system toxin MqsR Toxin
JG732_RS03485 718613..719008 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JG732_RS03490 719141..720748 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JG732_RS03495 720886..723144 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11290.00 Da        Isoelectric Point: 8.0440

>T38150 WP_063084548.1 NZ_AP024205:718315-718611 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELDLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T38150 NZ_AP024205:718315-718611 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGATTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT38150 WP_000650107.1 NZ_AP024205:718613-719008 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT38150 NZ_AP024205:718613-719008 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References