Detailed information of TA system TA038146

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2801946..2802253
• Replicon: chromosome
• Accession: NZ_AP024203
• Organism: Staphylococcus aureus strain SA23-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SA231_RS14030
• Protein ID: WP_011447039.1
• Coordinates: 2802077..2802253 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2801946..2802085 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA231_RS13990 (2797287)	2797287..2797547	+	261	WP_001791826.1	hypothetical protein	-
SA231_RS13995 (2797600)	2797600..2797950	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SA231_RS14000 (2798634)	2798634..2799083	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SA231_RS14005 (2799178)	2799178..2799513	-	336	Protein_2720	SH3 domain-containing protein	-
SA231_RS14010 (2800162)	2800162..2800653	-	492	WP_000919350.1	staphylokinase	-
SA231_RS14015 (2800844)	2800844..2801599	-	756	WP_000861038.1	CHAP domain-containing protein	-
SA231_RS14020 (2801611)	2801611..2801865	-	255	WP_000611512.1	phage holin	-
SA231_RS14025 (2801917)	2801917..2802024	+	108	WP_001791821.1	hypothetical protein	-
- (2801946)	2801946..2802085	+	140	NuclAT_0	-	Antitoxin
- (2801946)	2801946..2802085	+	140	NuclAT_0	-	Antitoxin
- (2801946)	2801946..2802085	+	140	NuclAT_0	-	Antitoxin
- (2801946)	2801946..2802085	+	140	NuclAT_0	-	Antitoxin
SA231_RS14030 (2802077)	2802077..2802253	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
SA231_RS14035 (2802403)	2802403..2802699	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SA231_RS14040 (2802757)	2802757..2803044	-	288	WP_001040261.1	hypothetical protein	-
SA231_RS14045 (2803091)	2803091..2803243	-	153	WP_001153681.1	hypothetical protein	-
SA231_RS14050 (2803233)	2803233..2807018	-	3786	WP_229345001.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak	2797600..2820807	23207

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38146 WP_011447039.1 NZ_AP024203:c2802253-2802077 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38146 NZ_AP024203:c2802253-2802077 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT38146 NZ_AP024203:2801946-2802085 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin