38141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) TMCS/-
Location 2339366..2339945 Replicon chromosome
Accession NZ_AP024203
Organism Staphylococcus aureus strain SA23-1

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag SA231_RS11535 Protein ID WP_001025401.1
Coordinates 2339700..2339945 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2339366..2339731 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA231_RS11495 (2336085) 2336085..2336666 - 582 WP_176426981.1 DUF2815 family protein -
SA231_RS11500 (2336692) 2336692..2337858 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SA231_RS11505 (2337855) 2337855..2338217 - 363 WP_229344986.1 hypothetical protein -
SA231_RS11510 (2338232) 2338232..2338555 - 324 WP_000175001.1 hypothetical protein -
SA231_RS11515 (2338634) 2338634..2338795 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SA231_RS11520 (2338808) 2338808..2339071 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SA231_RS11525 (2339096) 2339096..2339311 - 216 WP_001097552.1 hypothetical protein -
SA231_RS11530 (2339366) 2339366..2339731 + 366 WP_001128433.1 hypothetical protein Antitoxin
SA231_RS11535 (2339700) 2339700..2339945 - 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
SA231_RS11540 (2340001) 2340001..2340210 + 210 WP_000642492.1 hypothetical protein -
SA231_RS11545 (2340200) 2340200..2340343 - 144 WP_000939498.1 hypothetical protein -
SA231_RS11550 (2340372) 2340372..2341148 - 777 WP_001148544.1 Rha family transcriptional regulator -
SA231_RS11555 (2341162) 2341162..2341398 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
SA231_RS11560 (2341550) 2341550..2341864 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator -
SA231_RS11565 (2341877) 2341877..2342338 + 462 WP_000525004.1 hypothetical protein -
SA231_RS11570 (2342356) 2342356..2342940 + 585 WP_000825948.1 hypothetical protein -
SA231_RS11575 (2343170) 2343170..2343316 + 147 WP_001013104.1 hypothetical protein -
SA231_RS11580 (2343313) 2343313..2343927 - 615 WP_000191459.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 2298645..2367853 69208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-69)


Sequences


Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T38141 WP_001025401.1 NZ_AP024203:c2339945-2339700 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T38141 NZ_AP024203:c2339945-2339700 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 366 bp

>AT38141 NZ_AP024203:2339366-2339731 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7P609


Antitoxin

Download structure file

References