Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2331306..2331720 Replicon chromosome
Accession NZ_AP024203
Organism Staphylococcus aureus strain SA23-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SA231_RS11445 Protein ID WP_031267622.1
Coordinates 2331469..2331720 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SA231_RS11440 Protein ID WP_000028424.1
Coordinates 2331306..2331479 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA231_RS11400 (2326570) 2326570..2326860 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
SA231_RS11405 (2326994) 2326994..2327092 + 99 WP_001801650.1 hypothetical protein -
SA231_RS11410 (2327201) 2327201..2329648 - 2448 WP_000884870.1 VapE family protein -
SA231_RS11415 (2329936) 2329936..2330136 - 201 WP_000265252.1 DUF1514 family protein -
SA231_RS11420 (2330204) 2330204..2330356 - 153 WP_000595263.1 transcriptional activator RinB -
SA231_RS11425 (2330353) 2330353..2330559 - 207 WP_000195810.1 DUF1381 domain-containing protein -
SA231_RS11430 (2330596) 2330596..2331129 - 534 WP_063653166.1 dUTPase -
SA231_RS11435 (2331144) 2331144..2331305 - 162 WP_000889684.1 hypothetical protein -
SA231_RS11440 (2331306) 2331306..2331479 - 174 WP_000028424.1 hypothetical protein Antitoxin
SA231_RS11445 (2331469) 2331469..2331720 - 252 WP_031267622.1 DUF1024 family protein Toxin
SA231_RS11450 (2331713) 2331713..2332020 - 308 Protein_2249 hypothetical protein -
SA231_RS11455 (2332017) 2332017..2332364 - 348 WP_000979209.1 YopX family protein -
SA231_RS11460 (2332361) 2332361..2332741 - 381 WP_001668982.1 hypothetical protein -
SA231_RS11465 (2332744) 2332744..2332950 - 207 WP_000693989.1 hypothetical protein -
SA231_RS11470 (2332964) 2332964..2333212 - 249 WP_060474161.1 SAV1978 family virulence-associated passenger protein -
SA231_RS11475 (2333212) 2333212..2333466 - 255 WP_000022722.1 DUF3310 domain-containing protein -
SA231_RS11480 (2333463) 2333463..2333867 - 405 WP_044426014.1 SA1788 family PVL leukocidin-associated protein -
SA231_RS11485 (2333867) 2333867..2334052 - 186 WP_001164629.1 DUF3113 family protein -
SA231_RS11490 (2334065) 2334065..2336017 - 1953 WP_229345138.1 DNA polymerase -
SA231_RS11495 (2336085) 2336085..2336666 - 582 WP_176426981.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 2298645..2367853 69208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9419.35 Da        Isoelectric Point: 3.9476

>T38140 WP_031267622.1 NZ_AP024203:c2331720-2331469 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T38140 NZ_AP024203:c2331720-2331469 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT38140 WP_000028424.1 NZ_AP024203:c2331479-2331306 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT38140 NZ_AP024203:c2331479-2331306 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References