Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 440877..441061 Replicon chromosome
Accession NZ_AP024203
Organism Staphylococcus aureus strain SA23-1

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SA231_RS02345 Protein ID WP_000482647.1
Coordinates 440954..441061 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 440877..440937 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA231_RS02330 436463..436630 - 168 WP_031785511.1 hypothetical protein -
SA231_RS02335 436861..438594 - 1734 WP_000488492.1 ABC transporter ATP-binding protein -
SA231_RS02340 438643..440382 - 1740 WP_001064831.1 ABC transporter ATP-binding protein -
- 440877..440937 + 61 - - Antitoxin
SA231_RS02345 440954..441061 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SA231_RS02350 441195..441581 - 387 WP_000779354.1 flippase GtxA -
SA231_RS02355 441849..442991 + 1143 WP_001176860.1 glycerate kinase -
SA231_RS02360 443051..443710 + 660 WP_000831298.1 membrane protein -
SA231_RS02365 443890..445101 + 1212 WP_001191975.1 multidrug effflux MFS transporter -
SA231_RS02370 445224..445697 - 474 WP_000456491.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T38137 WP_000482647.1 NZ_AP024203:c441061-440954 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T38137 NZ_AP024203:c441061-440954 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT38137 NZ_AP024203:440877-440937 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References