Detailed information of TA system TA038070

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2049577..2049884
• Replicon: chromosome
• Accession: NZ_AP024170
• Organism: Staphylococcus aureus strain 834

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SA834_RS10080
• Protein ID: WP_011447039.1
• Coordinates: 2049708..2049884 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2049577..2049716 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA834_RS10040	2044916..2045176	+	261	WP_001791826.1	hypothetical protein	-
SA834_RS10045	2045229..2045579	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SA834_RS10050	2046264..2046713	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SA834_RS10055	2046808..2047143	-	336	Protein_1945	SH3 domain-containing protein	-
SA834_RS10060	2047793..2048284	-	492	WP_000919350.1	staphylokinase	-
SA834_RS10065	2048475..2049230	-	756	WP_000861038.1	CHAP domain-containing protein	-
SA834_RS10070	2049242..2049496	-	255	WP_000611512.1	phage holin	-
SA834_RS10075	2049548..2049655	+	108	WP_001791821.1	hypothetical protein	-
-	2049577..2049716	+	140	NuclAT_0	-	Antitoxin
-	2049577..2049716	+	140	NuclAT_0	-	Antitoxin
-	2049577..2049716	+	140	NuclAT_0	-	Antitoxin
-	2049577..2049716	+	140	NuclAT_0	-	Antitoxin
SA834_RS10080	2049708..2049884	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SA834_RS10085	2050034..2050330	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SA834_RS10090	2050388..2050675	-	288	WP_001040261.1	hypothetical protein	-
SA834_RS10095	2050722..2050874	-	153	WP_001153681.1	hypothetical protein	-
SA834_RS10100	2050864..2054649	-	3786	WP_000582178.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / sell / sec / tsst-1 / groEL	2045229..2111403	66174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T38070 WP_011447039.1 NZ_AP024170:c2049884-2049708 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T38070 NZ_AP024170:c2049884-2049708 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT38070 NZ_AP024170:2049577-2049716 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin