Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1294998..1295631 Replicon chromosome
Accession NZ_AP024165
Organism Vibrio alfacsensis strain 04Ya108

Toxin (Protein)


Gene name higB Uniprot ID A0A347UQS4
Locus tag VA249_RS06235 Protein ID WP_012600340.1
Coordinates 1294998..1295330 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VA249_RS06240 Protein ID WP_017049537.1
Coordinates 1295317..1295631 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VA249_RS06185 1290669..1290782 + 114 WP_104027845.1 DUF3265 domain-containing protein -
VA249_RS06190 (VYA_11340) 1290821..1291336 + 516 WP_221069380.1 DUF1643 domain-containing protein -
VA249_RS06195 (VYA_11350) 1291452..1292048 + 597 WP_221069382.1 methyltransferase domain-containing protein -
VA249_RS06200 (VYA_11360) 1292289..1292486 + 198 WP_054757413.1 hypothetical protein -
VA249_RS06205 1292541..1292630 + 90 WP_072829120.1 DUF3265 domain-containing protein -
VA249_RS06210 1293149..1293238 + 90 WP_074531724.1 DUF3265 domain-containing protein -
VA249_RS06215 1293265..1293828 + 564 WP_221069384.1 hypothetical protein -
VA249_RS06220 1293849..1293941 + 93 WP_193343211.1 DUF3265 domain-containing protein -
VA249_RS06225 (VYA_11380) 1293976..1294782 + 807 WP_221069394.1 hypothetical protein -
VA249_RS06230 1294803..1294895 + 93 WP_080277110.1 DUF3265 domain-containing protein -
VA249_RS06235 (VYA_11390) 1294998..1295330 + 333 WP_012600340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VA249_RS06240 (VYA_11400) 1295317..1295631 + 315 WP_017049537.1 DNA-binding transcriptional regulator Antitoxin
VA249_RS06245 1295646..1295738 + 93 WP_012841671.1 DUF3265 domain-containing protein -
VA249_RS06250 (VYA_11410) 1295830..1296075 + 246 WP_077261314.1 hypothetical protein -
VA249_RS06255 1296072..1296182 + 111 WP_077262477.1 DUF3265 domain-containing protein -
VA249_RS06260 (VYA_11420) 1296219..1297040 + 822 WP_221069396.1 phospholipase D-like domain-containing protein -
VA249_RS06265 (VYA_11430) 1297187..1297885 + 699 WP_221069398.1 hypothetical protein -
VA249_RS06270 (VYA_11440) 1298025..1298420 + 396 WP_225927118.1 GIY-YIG nuclease family protein -
VA249_RS06275 1298457..1298546 + 90 WP_079766072.1 DUF3265 domain-containing protein -
VA249_RS06280 (VYA_11450) 1298673..1298960 + 288 WP_017817947.1 hypothetical protein -
VA249_RS06285 (VYA_11460) 1299145..1299744 + 600 WP_221069402.1 hypothetical protein -
VA249_RS06290 1299771..1299863 + 93 WP_213872838.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1225667..1320873 95206
- inside Integron - - 1226253..1318506 92253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-104)

Antitoxin

(24-101)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 12906.76 Da        Isoelectric Point: 10.0960

>T38063 WP_012600340.1 NZ_AP024165:1294998-1295330 [Vibrio alfacsensis]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Download         Length: 333 bp

>T38063 NZ_AP024165:1294998-1295330 [Vibrio alfacsensis]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTTAGCGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGTGGCTCTCGCGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11704.17 Da        Isoelectric Point: 6.3290

>AT38063 WP_017049537.1 NZ_AP024165:1295317-1295631 [Vibrio alfacsensis]
MSNRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT38063 NZ_AP024165:1295317-1295631 [Vibrio alfacsensis]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAGCAGTTTAATA
TGTCTCGTGGTGTTTTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAGCAAGGGCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGTTGGTTCAGCGCCACCCAGAAACCCTGTCGCACATCGCTGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A347UQS4


Antitoxin

Source ID Structure

References