Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2880390..2881052 Replicon chromosome
Accession NZ_AP024145
Organism Methylobacterium indicum strain VL1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag miv_RS13520 Protein ID WP_082172198.1
Coordinates 2880390..2880671 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag miv_RS13525 Protein ID WP_048429576.1
Coordinates 2880732..2881052 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
miv_RS13495 2875674..2877053 + 1380 WP_207183134.1 GTPase HflX -
miv_RS13500 2877217..2877561 + 345 WP_207183135.1 hypothetical protein -
miv_RS13505 2877566..2877793 + 228 WP_207183489.1 DUF4926 domain-containing protein -
miv_RS13510 2877807..2878967 + 1161 WP_207183136.1 AAA family ATPase -
miv_RS13515 2879005..2880222 - 1218 WP_207183137.1 MFS transporter -
miv_RS13520 2880390..2880671 + 282 WP_082172198.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
miv_RS13525 2880732..2881052 + 321 WP_048429576.1 HigA family addiction module antidote protein Antitoxin
miv_RS13530 2881200..2882192 - 993 WP_048429577.1 catalase family peroxidase -
miv_RS13535 2882285..2882839 - 555 WP_207183138.1 GNAT family N-acetyltransferase -
miv_RS13540 2882854..2883453 - 600 WP_058618358.1 XRE family transcriptional regulator -
miv_RS13545 2883524..2884357 - 834 WP_207183139.1 nucleoside triphosphate pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10581.03 Da        Isoelectric Point: 9.1519

>T38044 WP_082172198.1 NZ_AP024145:2880390-2880671 [Methylobacterium indicum]
VIRSFSDERTEAVLNDQQPKGLPTSILKVARRKLRYLHSATSLDDLKLPPGNKLHPILHDRAGQHAIRINDQWRICVRWT
GQGPEAVEIADDH

Download         Length: 282 bp

>T38044 NZ_AP024145:2880390-2880671 [Methylobacterium indicum]
GTGATCCGCAGCTTCTCCGACGAAAGAACCGAAGCGGTGCTCAACGATCAGCAGCCGAAGGGATTGCCGACCAGTATCCT
GAAGGTCGCACGTCGCAAGCTGCGCTACCTTCACAGCGCAACGTCACTCGACGATTTGAAACTGCCACCGGGTAACAAGC
TGCATCCGATCCTGCACGATCGAGCGGGGCAGCATGCGATCCGGATCAACGATCAGTGGCGCATCTGCGTCCGCTGGACC
GGTCAAGGGCCCGAAGCGGTCGAGATCGCGGACGATCACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11907.74 Da        Isoelectric Point: 5.2185

>AT38044 WP_048429576.1 NZ_AP024145:2880732-2881052 [Methylobacterium indicum]
VAIELETEDLLPPLHPGEVLREEFMVPLGLTAYAVAKACGVPRTRIERIAREETPITADTALRLGRYFGMNPQVWINLQG
DYELRRAQRAIGAEIDRIRPLAREAA

Download         Length: 321 bp

>AT38044 NZ_AP024145:2880732-2881052 [Methylobacterium indicum]
GTGGCGATCGAACTGGAAACCGAAGACCTGCTTCCCCCCCTCCATCCTGGAGAGGTCCTGCGCGAGGAGTTCATGGTGCC
GCTCGGGCTGACGGCCTACGCGGTGGCCAAGGCCTGCGGGGTGCCGCGCACCCGGATCGAGCGGATCGCGCGGGAGGAGA
CGCCGATCACCGCCGATACCGCGCTCCGGCTCGGGCGCTACTTCGGGATGAACCCCCAGGTGTGGATCAATCTGCAGGGC
GATTACGAACTTCGGCGCGCCCAGCGGGCGATCGGGGCGGAGATCGACCGCATCCGGCCCCTGGCGCGGGAAGCGGCATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References