Detailed information of TA system TA038041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 584112..584663
• Replicon: chromosome
• Accession: NZ_AP024145
• Organism: Methylobacterium indicum strain VL1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: miv_RS02680
• Protein ID: WP_207181318.1
• Coordinates: 584112..584384 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0J6ULD8
• Locus tag: miv_RS02685
• Protein ID: WP_048430593.1
• Coordinates: 584400..584663 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
miv_RS02665	580332..581930	-	1599	WP_207181315.1	gamma-glutamyltransferase family protein	-
miv_RS02670	582200..582379	+	180	WP_048430596.1	hypothetical protein	-
miv_RS02675	582391..583950	+	1560	WP_207181316.1	glucan biosynthesis protein D	-
miv_RS02680	584112..584384	-	273	WP_207181318.1	Txe/YoeB family addiction module toxin	Toxin
miv_RS02685	584400..584663	-	264	WP_048430593.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
miv_RS02690	584964..587483	-	2520	WP_207181320.1	glycogen/starch/alpha-glucan phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10547.92 Da
• Isoelectric Point: 8.9575

>T38041 WP_207181318.1 NZ_AP024145:c584384-584112 [Methylobacterium indicum]
MKLTFSDDAWSDYVFWQGEDTATLERINALIKEIKRTPFTGTGKPEPLKFKLKGWWSRRISGEHRLVYRVSGSGSTHTLE
IAQCRWHYDD

Nucleotide

• Length: 273 bp

>T38041 NZ_AP024145:c584384-584112 [Methylobacterium indicum]
ATGAAGTTGACCTTCTCGGACGATGCCTGGAGCGATTATGTGTTCTGGCAGGGTGAGGACACGGCCACGCTGGAGCGGAT
CAATGCTCTCATCAAAGAGATCAAACGCACGCCCTTCACCGGGACGGGCAAGCCCGAGCCTTTGAAGTTCAAGCTCAAGG
GTTGGTGGTCGCGCCGGATCTCGGGGGAGCACCGACTCGTCTATCGTGTGAGCGGTTCCGGCTCGACCCATACCCTCGAG
ATCGCGCAATGCCGATGGCACTACGATGATTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9948.31 Da
• Isoelectric Point: 5.1273

>AT38041 WP_048430593.1 NZ_AP024145:c584663-584400 [Methylobacterium indicum]
MTHVSLTDFRQSIAAHFDRVERDREELVVTRQGHEPLVLLPLAELESLRETLHLLGTPANARRLMRSIEQLDAGQTIERA
LIEPDQP

Nucleotide

• Length: 264 bp

>AT38041 NZ_AP024145:c584663-584400 [Methylobacterium indicum]
ATGACTCATGTGAGCCTGACCGACTTTCGACAGAGCATCGCCGCCCATTTCGACAGGGTCGAGCGTGACCGCGAAGAGCT
GGTCGTCACCCGCCAGGGTCACGAACCGCTGGTGTTGCTGCCACTCGCCGAGTTGGAGAGCCTCCGGGAGACCCTGCACC
TGCTGGGCACGCCCGCCAATGCCCGGCGACTGATGCGGTCGATCGAGCAGCTCGACGCAGGTCAAACGATCGAACGCGCG
CTCATCGAACCCGATCAGCCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0J6ULD8