Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4868418..4868675 Replicon chromosome
Accession NZ_AP024126
Organism Escherichia coli strain NS-NP030

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag FFJ14_RS23720 Protein ID WP_001135738.1
Coordinates 4868418..4868570 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 4868621..4868675 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFJ14_RS23690 4864516..4865175 + 660 WP_000747625.1 OmpA family lipoprotein -
FFJ14_RS23695 4865279..4866253 + 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
FFJ14_RS23700 4866303..4867013 - 711 WP_000190516.1 DUF3053 domain-containing protein -
FFJ14_RS23705 4867447..4867737 + 291 WP_000455798.1 HTH-type transcriptional regulator -
FFJ14_RS23710 4868018..4868230 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
FFJ14_RS23715 4868370..4868429 + 60 WP_212591412.1 hypothetical protein -
FFJ14_RS23720 4868418..4868570 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 4868621..4868675 + 55 - - Antitoxin
FFJ14_RS23725 4868896..4870965 - 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
FFJ14_RS23730 4870975..4871886 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
FFJ14_RS23735 4871981..4872280 - 300 WP_000980111.1 YsaB family lipoprotein -
FFJ14_RS23740 4872455..4873450 + 996 WP_063113396.1 O-acetyltransferase WecH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T38005 WP_001135738.1 NZ_AP024126:c4868570-4868418 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T38005 NZ_AP024126:c4868570-4868418 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT38005 NZ_AP024126:4868621-4868675 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References