Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 615560..615818 Replicon chromosome
Accession NZ_AP024126
Organism Escherichia coli strain NS-NP030

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FFJ14_RS02965 Protein ID WP_000809168.1
Coordinates 615560..615712 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 615761..615818 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFJ14_RS02945 610801..611514 - 714 WP_001102383.1 acidic protein MsyB -
FFJ14_RS02950 611540..611944 - 405 WP_000843559.1 DUF2541 family protein -
FFJ14_RS02955 612321..614237 + 1917 WP_000516135.1 molecular chaperone DnaK -
FFJ14_RS02960 614326..615456 + 1131 WP_001118464.1 molecular chaperone DnaJ -
FFJ14_RS02965 615560..615712 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 615761..615818 + 58 - - Antitoxin
FFJ14_RS02970 616298..617464 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
FFJ14_RS02975 617530..618429 + 900 WP_001300855.1 transcriptional activator NhaR -
FFJ14_RS02980 618468..619426 - 959 Protein_582 fimbrial family protein -
FFJ14_RS02985 619439..620770 - 1332 Protein_583 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T37974 WP_000809168.1 NZ_AP024126:c615712-615560 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T37974 NZ_AP024126:c615712-615560 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT37974 NZ_AP024126:615761-615818 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References