Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4125158..4125416 Replicon chromosome
Accession NZ_AP024114
Organism Escherichia coli strain JML285

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FFF71_RS19790 Protein ID WP_000809168.1
Coordinates 4125264..4125416 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4125158..4125215 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFF71_RS19770 4120205..4121536 + 1332 Protein_3875 fimbria/pilus outer membrane usher protein -
FFF71_RS19775 4121549..4122508 + 960 WP_040089989.1 hypothetical protein -
FFF71_RS19780 4122547..4123446 - 900 WP_001300855.1 transcriptional activator NhaR -
FFF71_RS19785 4123512..4124678 - 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
- 4125158..4125215 - 58 - - Antitoxin
FFF71_RS19790 4125264..4125416 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FFF71_RS19795 4125520..4126650 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FFF71_RS19800 4126739..4128655 - 1917 WP_000516135.1 molecular chaperone DnaK -
FFF71_RS19805 4129032..4129436 + 405 WP_000843559.1 DUF2541 family protein -
FFF71_RS19810 4129462..4130175 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T37920 WP_000809168.1 NZ_AP024114:4125264-4125416 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T37920 NZ_AP024114:4125264-4125416 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT37920 NZ_AP024114:c4125215-4125158 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References