Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 167204..167461 Replicon chromosome
Accession NZ_AP024114
Organism Escherichia coli strain JML285

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag FFF71_RS00790 Protein ID WP_001135738.1
Coordinates 167309..167461 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 167204..167258 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFF71_RS00770 162429..163424 - 996 WP_001182653.1 O-acetyltransferase WecH -
FFF71_RS00775 163599..163898 + 300 WP_000980111.1 YsaB family lipoprotein -
FFF71_RS00780 163993..164904 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
FFF71_RS00785 164914..166983 + 2070 WP_137515021.1 glycine--tRNA ligase subunit beta -
- 167204..167258 - 55 - - Antitoxin
FFF71_RS00790 167309..167461 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
FFF71_RS00795 167450..167509 - 60 WP_212591412.1 hypothetical protein -
FFF71_RS00800 167649..167861 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
FFF71_RS00805 168142..168432 - 291 WP_000455798.1 HTH-type transcriptional regulator -
FFF71_RS00810 168866..169576 + 711 WP_000190517.1 DUF3053 domain-containing protein -
FFF71_RS00815 169626..170600 - 975 WP_040089948.1 glyoxylate/hydroxypyruvate reductase GhrB -
FFF71_RS00820 170704..171363 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T37900 WP_001135738.1 NZ_AP024114:167309-167461 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T37900 NZ_AP024114:167309-167461 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT37900 NZ_AP024114:c167258-167204 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References