Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 46265..46519 | Replicon | plasmid ECSC054_P1 |
| Accession | NZ_AP024113 | ||
| Organism | Escherichia coli strain ECSC054 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | FE985_RS25505 | Protein ID | WP_001312851.1 |
| Coordinates | 46265..46414 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 46458..46519 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FE985_RS25460 (41268) | 41268..42038 | + | 771 | WP_000712166.1 | molybdopterin-dependent oxidoreductase | - |
| FE985_RS25465 (42068) | 42068..42316 | + | 249 | WP_000738203.1 | hypothetical protein | - |
| FE985_RS25470 (42466) | 42466..42564 | - | 99 | WP_137491101.1 | transposase | - |
| FE985_RS25475 (42757) | 42757..43065 | + | 309 | Protein_51 | transposase | - |
| FE985_RS25485 (44093) | 44093..44950 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| FE985_RS25490 (44943) | 44943..45425 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| FE985_RS26215 (45418) | 45418..45465 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| FE985_RS26220 (45456) | 45456..45707 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| FE985_RS25500 (45724) | 45724..45981 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| FE985_RS25505 (46265) | 46265..46414 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (46458) | 46458..46519 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (46458) | 46458..46519 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (46458) | 46458..46519 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (46458) | 46458..46519 | + | 62 | NuclAT_1 | - | Antitoxin |
| FE985_RS25510 (46775) | 46775..46849 | - | 75 | Protein_58 | endonuclease | - |
| FE985_RS25515 (47095) | 47095..47307 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| FE985_RS25520 (47443) | 47443..48003 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| FE985_RS25525 (48106) | 48106..48966 | - | 861 | WP_000704513.1 | alpha/beta hydrolase | - |
| FE985_RS25530 (49025) | 49025..49519 | - | 495 | WP_001563729.1 | type-F conjugative transfer system pilin acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B | iucA / iucB / iucC / iucD / iutA | 1..126311 | 126311 | |
| - | flank | IS/Tn | - | - | 42799..43065 | 266 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T37892 WP_001312851.1 NZ_AP024113:c46414-46265 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T37892 NZ_AP024113:c46414-46265 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 62 bp
>AT37892 NZ_AP024113:46458-46519 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
