Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 101173..101745 Replicon chromosome
Accession NZ_AP024110
Organism Methyloradius palustris strain Zm11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ZMTM_RS00505 Protein ID WP_221764411.1
Coordinates 101464..101745 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ZMTM_RS00500 Protein ID WP_221765511.1
Coordinates 101173..101448 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZMTM_RS00465 (ZMTM_00830) 96671..98011 - 1341 WP_221764404.1 hypothetical protein -
ZMTM_RS00470 (ZMTM_00840) 98008..98226 - 219 WP_221764405.1 hypothetical protein -
ZMTM_RS00475 98223..98378 - 156 WP_221764406.1 hypothetical protein -
ZMTM_RS00480 (ZMTM_00850) 98375..99046 - 672 WP_221764407.1 helix-turn-helix domain-containing protein -
ZMTM_RS00485 (ZMTM_00860) 99218..99682 - 465 WP_221764408.1 helix-turn-helix transcriptional regulator -
ZMTM_RS00490 (ZMTM_00870) 99878..100420 + 543 WP_221764409.1 hypothetical protein -
ZMTM_RS00495 (ZMTM_00880) 100402..101166 + 765 WP_221764410.1 hypothetical protein -
ZMTM_RS00500 (ZMTM_00890) 101173..101448 - 276 WP_221765511.1 HigA family addiction module antitoxin Antitoxin
ZMTM_RS00505 (ZMTM_00900) 101464..101745 - 282 WP_221764411.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ZMTM_RS00510 (ZMTM_00920) 102194..103627 + 1434 WP_221764412.1 sigma-54 dependent transcriptional regulator -
ZMTM_RS00515 (ZMTM_00930) 103627..105030 + 1404 WP_221764413.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-88)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10482.83 Da        Isoelectric Point: 7.4684

>T37862 WP_221764411.1 NZ_AP024110:c101745-101464 [Methyloradius palustris]
MIKSFQHKGLEQFFRTGSKAGIQPHHATKLNIQLTALNAAESAEDLRAPGAWRLHQLTGELAGFWSITVNGNWRVIFKFN
GSDAELVDYLDYH

Download         Length: 282 bp

>T37862 NZ_AP024110:c101745-101464 [Methyloradius palustris]
ATGATTAAAAGTTTTCAGCACAAAGGCTTGGAGCAGTTCTTTAGGACTGGTAGCAAAGCTGGCATCCAGCCACACCATGC
AACCAAACTAAATATCCAGCTCACCGCCTTGAATGCAGCGGAATCAGCTGAAGACTTAAGAGCACCAGGTGCATGGCGAC
TTCATCAACTAACTGGTGAACTGGCTGGCTTCTGGTCAATAACGGTAAATGGTAATTGGCGTGTGATTTTTAAGTTTAAT
GGCAGCGATGCCGAGCTTGTTGATTACTTGGATTATCACTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10134.41 Da        Isoelectric Point: 7.1418

>AT37862 WP_221765511.1 NZ_AP024110:c101448-101173 [Methyloradius palustris]
MHNPAHPGEVLKEYLPENLSITDAASHLGVTRAALSRVLNSRAGISAEMDLRLSDALGTSPGFWARIQVQYDIWQAKQHH
HTHIERFPQAA

Download         Length: 276 bp

>AT37862 NZ_AP024110:c101448-101173 [Methyloradius palustris]
ATGCACAACCCCGCACACCCTGGCGAGGTATTGAAAGAATACCTGCCTGAGAATTTAAGCATCACTGATGCGGCAAGTCA
CCTGGGAGTGACGCGTGCTGCCTTGTCTCGCGTACTAAACAGCAGGGCTGGTATTAGTGCTGAAATGGATCTGCGCCTAT
CTGATGCCTTGGGTACATCGCCTGGCTTTTGGGCTCGCATTCAGGTGCAATACGATATCTGGCAAGCTAAGCAACACCAT
CACACGCACATTGAGCGTTTTCCACAGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References