Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1685960..1686599 Replicon chromosome
Accession NZ_AP024093
Organism Haemophilus haemolyticus strain 2019-19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Hhaem_RS08330 Protein ID WP_223893448.1
Coordinates 1686294..1686599 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Hhaem_RS08325 Protein ID WP_223893447.1
Coordinates 1685960..1686283 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Hhaem_RS08305 (Hhaem_15830) 1681703..1681876 - 174 WP_005646606.1 DUF5363 family protein -
Hhaem_RS08310 (Hhaem_15840) 1681873..1683717 - 1845 WP_223893444.1 GNAT family N-acetyltransferase -
Hhaem_RS08315 (Hhaem_15850) 1683722..1684063 - 342 WP_118776529.1 SirB2 family protein -
Hhaem_RS08320 (Hhaem_15860) 1684125..1685795 - 1671 WP_223893446.1 energy-dependent translational throttle protein EttA -
Hhaem_RS08325 (Hhaem_15870) 1685960..1686283 - 324 WP_223893447.1 HigA family addiction module antitoxin Antitoxin
Hhaem_RS08330 (Hhaem_15880) 1686294..1686599 - 306 WP_223893448.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Hhaem_RS08335 (Hhaem_15890) 1686924..1687544 + 621 WP_223893449.1 zinc transporter binding subunit ZevA -
Hhaem_RS08340 (Hhaem_15900) 1687547..1688515 + 969 WP_223893450.1 zinc transporter permease subunit ZevB -
Hhaem_RS08350 (Hhaem_15910) 1689129..1691168 + 2040 WP_223893451.1 excinuclease ABC subunit UvrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12122.76 Da        Isoelectric Point: 9.1259

>T37831 WP_223893448.1 NZ_AP024093:c1686599-1686294 [Haemophilus haemolyticus]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLSKVLARKLDMISAAEGINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T37831 NZ_AP024093:c1686599-1686294 [Haemophilus haemolyticus]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATGCTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTGGATATGATAAGTGCTGCAGAAGGCATCAATGATTTACGTTCTC
CGCCGGCTAATCACTTAGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTAAATAAACAATATCGCCTA
ATTTTTAAATATGAGAATAACGAAGTAAATAATTTATATTTAGATCCTCATTCTTATAATTTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12346.19 Da        Isoelectric Point: 7.4049

>AT37831 WP_223893447.1 NZ_AP024093:c1686283-1685960 [Haemophilus haemolyticus]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTVSNIVNNSSRITLEMSVKLAKAFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHATSTFAM

Download         Length: 324 bp

>AT37831 NZ_AP024093:c1686283-1685960 [Haemophilus haemolyticus]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAATGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACTGTAAGTAATATCGTTAATAATAGTTCACGAATTACGCTAGAAATGT
CAGTTAAACTTGCTAAAGCATTTGATACCACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGCTACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References