Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1331718..1332367 Replicon chromosome
Accession NZ_AP023447
Organism Enterobacter roggenkampii strain OIPH-N260

Toxin (Protein)


Gene name higB Uniprot ID A0A1S2AEP5
Locus tag OIPHN260_RS06600 Protein ID WP_045416590.1
Coordinates 1332005..1332367 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S2AD04
Locus tag OIPHN260_RS06595 Protein ID WP_047746098.1
Coordinates 1331718..1332017 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIPHN260_RS06585 1328142..1330115 + 1974 WP_202324474.1 PhoX family phosphatase -
OIPHN260_RS06590 1330219..1331607 + 1389 WP_047746095.1 phenylalanine transporter -
OIPHN260_RS06595 1331718..1332017 - 300 WP_047746098.1 helix-turn-helix transcriptional regulator Antitoxin
OIPHN260_RS06600 1332005..1332367 - 363 WP_045416590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIPHN260_RS06605 1332573..1333808 + 1236 WP_032663994.1 MFS transporter -
OIPHN260_RS06610 1333824..1334849 + 1026 WP_047746100.1 sugar phosphate isomerase/epimerase -
OIPHN260_RS06615 1334842..1335984 + 1143 WP_047746102.1 Gfo/Idh/MocA family oxidoreductase -
OIPHN260_RS06620 1336060..1337031 + 972 WP_021241589.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13908.76 Da        Isoelectric Point: 5.1960

>T37768 WP_045416590.1 NZ_AP023447:c1332367-1332005 [Enterobacter roggenkampii]
MWNVETTDRFDDWFFEQTTALKEDVLATMHILAEFGPTLGRPYVDTVKDSAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMIALADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T37768 NZ_AP023447:c1332367-1332005 [Enterobacter roggenkampii]
ATGTGGAACGTCGAGACAACGGACAGATTTGACGACTGGTTCTTTGAACAAACAACAGCATTAAAAGAAGATGTGCTGGC
GACGATGCATATTCTTGCTGAATTTGGCCCAACCCTGGGGCGACCATACGTAGACACCGTGAAGGATTCAGCCTATGCAA
ACATGAAAGAGTTACGTATTCAGCATGCGGGTAATCCCATCAGAGCCTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATCGCGCTGGCTGACGTTGAATA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10906.70 Da        Isoelectric Point: 9.8627

>AT37768 WP_047746098.1 NZ_AP023447:c1332017-1331718 [Enterobacter roggenkampii]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT37768 NZ_AP023447:c1332017-1331718 [Enterobacter roggenkampii]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATAGCGGCTAAAGTTGAAGTGATGCG
CAGAATTGTTGCCCTGAACCAGCTGCGGGAAGAGCTCAATATTTCCCAGACAGAACTGGCCGCAGCAATGGGGGTAAAAC
AACCCACTTTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGCTACCGAATGGGAAACGGATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2AEP5

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2AD04

References