37741

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4143765..4144458 Replicon chromosome
Accession NZ_AP023433
Organism Escherichia coli strain M719

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag M2043_RS19955 Protein ID WP_000415585.1
Coordinates 4144162..4144458 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M2043_RS19950 Protein ID WP_000650107.1
Coordinates 4143765..4144160 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2043_RS19940 (4139629) 4139629..4141887 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
M2043_RS19945 (4142025) 4142025..4143632 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
M2043_RS19950 (4143765) 4143765..4144160 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M2043_RS19955 (4144162) 4144162..4144458 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
M2043_RS19960 (4144663) 4144663..4145145 - 483 WP_000183505.1 GyrI-like domain-containing protein -
M2043_RS19965 (4145198) 4145198..4145590 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M2043_RS19970 (4145742) 4145742..4146401 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
M2043_RS19975 (4146398) 4146398..4147747 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
M2043_RS19980 (4147793) 4147793..4148125 - 333 WP_000914690.1 DUF2645 family protein -
M2043_RS19985 (4148132) 4148132..4148842 - 711 WP_000834030.1 hypothetical protein -
M2043_RS19990 (4148845) 4148845..4149324 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T37741 WP_000415585.1 NZ_AP023433:c4144458-4144162 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T37741 NZ_AP023433:c4144458-4144162 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT37741 WP_000650107.1 NZ_AP023433:c4144160-4143765 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT37741 NZ_AP023433:c4144160-4143765 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References