Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 754687..755341 Replicon chromosome
Accession NZ_AP023392
Organism Streptococcus suis strain DAT300

Toxin (Protein)


Gene name higB Uniprot ID G7SDV0
Locus tag H7679_RS03815 Protein ID WP_014637766.1
Coordinates 754687..755052 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G7SDV1
Locus tag H7679_RS03820 Protein ID WP_014637767.1
Coordinates 755042..755341 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7679_RS03800 750876..751469 - 594 WP_024395872.1 DUF1361 domain-containing protein -
H7679_RS03805 751625..753628 + 2004 WP_024395873.1 methionine--tRNA ligase -
H7679_RS03810 753690..754643 + 954 WP_024395874.1 competence protein CoiA -
H7679_RS03815 754687..755052 + 366 WP_014637766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7679_RS03820 755042..755341 + 300 WP_014637767.1 helix-turn-helix transcriptional regulator Antitoxin
H7679_RS03825 755451..757253 + 1803 WP_024395875.1 oligoendopeptidase F -
H7679_RS03830 757255..757698 + 444 WP_024395876.1 hypothetical protein -
H7679_RS03835 757709..758257 + 549 WP_024395877.1 hypothetical protein -
H7679_RS03840 758332..759051 + 720 WP_050573105.1 O-methyltransferase -
H7679_RS03845 759113..760114 + 1002 WP_024385839.1 peptidylprolyl isomerase PrsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14435.66 Da        Isoelectric Point: 10.1354

>T37684 WP_014637766.1 NZ_AP023392:754687-755052 [Streptococcus suis]
MYTIYFYKDKNGREPVLEYLRELASKKGKDSRIKLNKINDYIELLSQLGTQIGEPYVKHLEGNIWELRPLRDRILFVAWY
DGSFVLLHHFVKRSQKTPRRELEKAQRELADLKERGINNGK

Download         Length: 366 bp

>T37684 NZ_AP023392:754687-755052 [Streptococcus suis]
ATGTACACTATTTATTTTTATAAGGATAAAAATGGAAGGGAGCCTGTTTTAGAGTATCTGAGGGAGCTTGCATCTAAAAA
GGGGAAAGATAGCAGGATTAAATTGAATAAGATAAATGATTATATTGAACTTTTAAGTCAACTGGGAACTCAAATTGGTG
AACCATATGTGAAGCACTTGGAAGGTAATATTTGGGAATTGCGTCCCTTAAGAGATAGGATTTTATTTGTCGCATGGTAT
GATGGGAGTTTTGTTTTACTGCATCATTTTGTGAAACGGTCACAGAAAACACCACGGAGGGAGCTTGAAAAGGCTCAACG
TGAGCTGGCAGACTTGAAAGAAAGGGGTATTAACAATGGAAAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11058.73 Da        Isoelectric Point: 7.2059

>AT37684 WP_014637767.1 NZ_AP023392:755042-755341 [Streptococcus suis]
MENSAIGSNWQSVRSELFSEKEIIESDLRVAIMSELIKARHEQGVSQKRLEELSGVSQPVIARMETGKTSPQLDTILKVL
ASLGKTLAVVPLKQERHFQ

Download         Length: 300 bp

>AT37684 NZ_AP023392:755042-755341 [Streptococcus suis]
ATGGAAAATAGTGCAATTGGTAGTAACTGGCAATCGGTACGGTCTGAACTCTTCAGTGAGAAGGAAATCATAGAAAGTGA
TTTGCGTGTGGCAATTATGAGCGAACTGATAAAAGCAAGGCATGAACAGGGAGTAAGTCAGAAAAGACTAGAGGAGCTAA
GCGGGGTGAGTCAACCAGTTATTGCAAGAATGGAAACAGGTAAAACTAGTCCACAATTGGACACTATCTTGAAGGTATTG
GCTAGTCTAGGCAAAACTTTAGCAGTTGTGCCTTTGAAACAGGAACGACATTTTCAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDV0

Antitoxin

Source ID Structure
AlphaFold DB G7SDV1

References