Detailed information of TA system TA037683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1937708..1938227
• Replicon: chromosome
• Accession: NZ_AP023391
• Organism: Streptococcus suis strain DAT299

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H7677_RS09510
• Protein ID: WP_172059776.1
• Coordinates: 1937708..1937965 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0K2E7Z9
• Locus tag: H7677_RS09515
• Protein ID: WP_002939010.1
• Coordinates: 1937967..1938227 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7677_RS09495	1934179..1935909	-	1731	WP_184493568.1	hypothetical protein	-
H7677_RS09500	1936272..1937180	-	909	WP_172059780.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
H7677_RS09505	1937164..1937694	-	531	WP_172059778.1	DUF1697 domain-containing protein	-
H7677_RS09510	1937708..1937965	-	258	WP_172059776.1	Txe/YoeB family addiction module toxin	Toxin
H7677_RS09515	1937967..1938227	-	261	WP_002939010.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H7677_RS09520	1938303..1938758	-	456	WP_015647468.1	8-oxo-dGTP diphosphatase	-
H7677_RS09525	1938762..1939130	-	369	WP_024383247.1	hypothetical protein	-
H7677_RS09530	1939123..1939692	-	570	WP_105095029.1	ribonuclease M5	-
H7677_RS09535	1939676..1940458	-	783	WP_172059772.1	TatD family hydrolase	-
H7677_RS09540	1940565..1940702	-	138	WP_002939016.1	50S ribosomal protein L34	-
H7677_RS09545	1940870..1941865	-	996	WP_172059770.1	protein jag	-
H7677_RS09550	1941885..1942697	-	813	WP_184493570.1	YidC/Oxa1 family membrane protein insertase	-
H7677_RS09555	1942681..1943040	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1936272..1957522	21250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10204.69 Da
• Isoelectric Point: 6.7162

>T37683 WP_172059776.1 NZ_AP023391:c1937965-1937708 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADLLCILSL
KDHYG

Nucleotide

• Length: 258 bp

>T37683 NZ_AP023391:c1937965-1937708 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAGCCAGAACCCTTGAAGTATGACTATCAGG
GGGCCTGGTCAAGAAGGATTGATGCCGAAAATCGACTGATTTATATGGTGGAGGCTGATTTGTTGTGCATCCTGTCGCTA
AAGGATCATTATGGGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9980.36 Da
• Isoelectric Point: 5.7134

>AT37683 WP_002939010.1 NZ_AP023391:c1938227-1937967 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Nucleotide

• Length: 261 bp

>AT37683 NZ_AP023391:c1938227-1937967 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAAGACTATATGAAAAAGGTCAATGACGAGTTTGAGCCCTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0K2E7Z9