Detailed information of TA system TA037666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3344508..3345205
• Replicon: chromosome
• Accession: NZ_AP023360
• Organism: Catellatospora sp. IY07-71

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CS0771_RS15310
• Protein ID: WP_244870805.1
• Coordinates: 3344837..3345205 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CS0771_RS15305
• Protein ID: WP_212841598.1
• Coordinates: 3344508..3344840 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS0771_RS15285 (CS0771_30460)	3340316..3342355	+	2040	WP_244870804.1	glycogen debranching N-terminal domain-containing protein	-
CS0771_RS15290 (CS0771_30470)	3342357..3343196	-	840	WP_212841595.1	SigB/SigF/SigG family RNA polymerase sigma factor	-
CS0771_RS15295 (CS0771_30480)	3343263..3343676	-	414	WP_212841596.1	heavy metal-binding domain-containing protein	-
CS0771_RS15300 (CS0771_30490)	3343816..3344301	+	486	WP_212841597.1	8-oxo-dGTP diphosphatase	-
CS0771_RS15305 (CS0771_30500)	3344508..3344840	-	333	WP_212841598.1	helix-turn-helix transcriptional regulator	Antitoxin
CS0771_RS15310 (CS0771_30510)	3344837..3345205	-	369	WP_244870805.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CS0771_RS15315 (CS0771_30520)	3345283..3346467	-	1185	WP_212841600.1	ABC transporter permease	-
CS0771_RS15320 (CS0771_30530)	3346551..3347231	-	681	Protein_3014	ABC transporter ATP-binding protein	-
CS0771_RS15325 (CS0771_30540)	3347228..3348568	-	1341	WP_212841602.1	efflux RND transporter periplasmic adaptor subunit	-
CS0771_RS15330 (CS0771_30550)	3348662..3349807	+	1146	WP_212841603.1	AI-2E family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (21-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-97)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14072.98 Da
• Isoelectric Point: 5.0150

>T37666 WP_244870805.1 NZ_AP023360:c3345205-3344837 [Catellatospora sp. IY07-71]
VWEINLHEEVETWFLELCATDPISADLVAEAIDLLAEHGPALGRPLVDRIQTSRFHHMKELRPGSSGSTEVRLLFAFDPL
REAIFLIAGDKSGQWKRWYQSAVPLADERLEEHLTRLKEERR

Nucleotide

• Length: 369 bp

>T37666 NZ_AP023360:c3345205-3344837 [Catellatospora sp. IY07-71]
GTGTGGGAAATCAACCTCCACGAAGAGGTCGAGACTTGGTTCCTGGAGCTGTGCGCCACCGATCCGATCAGCGCCGACCT
GGTCGCCGAGGCCATCGATCTGCTCGCCGAGCACGGCCCGGCGCTCGGCCGACCGTTGGTCGATCGGATTCAGACCAGCA
GATTCCACCATATGAAGGAACTGCGACCGGGCTCCTCCGGCTCGACAGAGGTTCGGCTGCTCTTCGCGTTCGACCCGCTA
CGCGAGGCGATCTTCCTTATCGCCGGGGACAAGTCCGGACAGTGGAAACGGTGGTACCAGAGCGCGGTTCCCCTGGCAGA
CGAACGGCTTGAAGAACATCTGACGAGGCTGAAGGAGGAACGGCGATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11933.52 Da
• Isoelectric Point: 10.0754

>AT37666 WP_212841598.1 NZ_AP023360:c3344840-3344508 [Catellatospora sp. IY07-71]
MTAPSNWRDVKAKARTADPTWDTEERTVRRARMREEMLASVSGAQLAEIRKQLGLTQSQLAETAGLSQARISQIESGAAT
SLESLRAYVTGLGGHLDIVARIGNIQLNIA

Nucleotide

• Length: 333 bp

>AT37666 NZ_AP023360:c3344840-3344508 [Catellatospora sp. IY07-71]
ATGACCGCCCCATCGAATTGGCGGGATGTGAAGGCCAAGGCCCGCACCGCGGACCCCACCTGGGACACCGAGGAGCGCAC
GGTCCGTCGAGCCCGCATGCGCGAGGAGATGCTTGCCTCCGTCAGCGGCGCCCAGCTCGCGGAGATCCGCAAGCAGCTCG
GCCTCACCCAAAGCCAGCTCGCCGAGACCGCGGGTCTGTCCCAGGCTCGGATCAGTCAAATCGAGAGCGGTGCCGCGACC
AGTCTGGAGAGTCTGCGCGCCTATGTGACCGGGCTCGGCGGCCACCTCGACATCGTCGCCCGCATCGGCAACATCCAGCT
CAACATCGCCTGA