Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 782880..783550 Replicon chromosome
Accession NZ_AP023359
Organism Polymorphospora rubra strain NBRC 101157

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Prubr_RS03450 Protein ID WP_281425877.1
Coordinates 783194..783550 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Prubr_RS03445 Protein ID WP_212821572.1
Coordinates 782880..783194 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Prubr_RS03420 (Prubr_07070) 778325..778996 - 672 WP_212821564.1 ABC transporter ATP-binding protein -
Prubr_RS03425 (Prubr_07080) 778993..779520 - 528 WP_212821566.1 PadR family transcriptional regulator -
Prubr_RS03430 (Prubr_07090) 779680..780198 + 519 WP_212827408.1 SigE family RNA polymerase sigma factor -
Prubr_RS03435 (Prubr_07100) 780234..781694 + 1461 WP_212821570.1 hypothetical protein -
Prubr_RS03440 (Prubr_07110) 782030..782458 - 429 WP_212821571.1 hypothetical protein -
Prubr_RS03445 (Prubr_07120) 782880..783194 - 315 WP_212821572.1 helix-turn-helix transcriptional regulator Antitoxin
Prubr_RS03450 (Prubr_07130) 783194..783550 - 357 WP_281425877.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Prubr_RS03455 (Prubr_07140) 783550..784818 - 1269 WP_212821573.1 DUF4143 domain-containing protein -
Prubr_RS03460 (Prubr_07150) 784892..785917 - 1026 WP_212821574.1 hypothetical protein -
Prubr_RS03465 (Prubr_07160) 785914..786258 - 345 WP_246568271.1 calcium-binding protein -
Prubr_RS03475 (Prubr_07170) 786485..788194 - 1710 WP_212821575.1 insulinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12998.01 Da        Isoelectric Point: 9.1318

>T37664 WP_281425877.1 NZ_AP023359:c783550-783194 [Polymorphospora rubra]
MRGTCPANVIPTPACPKAAYRSVNAAIDMLAETGPGLALPLVDTLRDSSISNLKELRPRSGRDVAIRVLFVFDPWSQAVL
LVAGNKAGDWTRWYEKAIPVAEVAYEGWLAFERKRREG

Download         Length: 357 bp

>T37664 NZ_AP023359:c783550-783194 [Polymorphospora rubra]
ATGAGAGGTACCTGCCCGGCCAACGTCATCCCTACTCCGGCGTGTCCAAAGGCGGCGTACCGGTCCGTGAACGCGGCGAT
CGACATGCTTGCTGAGACCGGTCCGGGCCTGGCCCTTCCACTGGTCGACACTCTTCGGGATTCAAGCATCAGCAACCTTA
AGGAGCTGCGGCCGAGGTCCGGCCGCGATGTCGCCATCCGGGTTCTGTTCGTCTTCGACCCATGGTCGCAGGCGGTCCTC
CTGGTCGCCGGCAACAAGGCCGGCGACTGGACACGGTGGTATGAGAAGGCGATCCCGGTCGCCGAGGTCGCCTATGAGGG
CTGGCTTGCCTTCGAGAGGAAACGGAGGGAGGGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11786.08 Da        Isoelectric Point: 4.4965

>AT37664 WP_212821572.1 NZ_AP023359:c783194-782880 [Polymorphospora rubra]
MVDFHDWDDIRAELHDGDDAALDAERARTEAWVSAFHLAEERKRLGLTQRQVAELMGVTPGRVSQIENGDLDANEVATLS
RYARALGARMRIIFDYDSDLRQIA

Download         Length: 315 bp

>AT37664 NZ_AP023359:c783194-782880 [Polymorphospora rubra]
ATGGTCGACTTCCATGACTGGGACGACATCCGCGCCGAGCTGCACGATGGGGACGACGCCGCGCTCGATGCGGAACGCGC
CCGCACCGAGGCATGGGTCAGCGCGTTCCACCTTGCCGAGGAGCGCAAGCGTCTCGGTCTCACCCAGCGGCAGGTGGCGG
AACTGATGGGGGTCACGCCCGGCCGGGTGAGTCAAATCGAGAACGGCGATCTGGACGCCAACGAGGTGGCGACCCTCAGC
CGGTATGCACGAGCACTGGGCGCCCGGATGCGAATCATTTTCGACTACGACAGCGACCTCCGTCAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References