Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 686647..687325 Replicon chromosome
Accession NZ_AP023359
Organism Polymorphospora rubra strain NBRC 101157

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Prubr_RS03015 Protein ID WP_212821399.1
Coordinates 686957..687325 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Prubr_RS03010 Protein ID WP_212821397.1
Coordinates 686647..686964 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Prubr_RS03000 681775..683900 + 2126 Protein_597 AAA family ATPase -
Prubr_RS03005 (Prubr_06210) 684089..686626 + 2538 WP_212821395.1 ABC transporter permease -
Prubr_RS03010 (Prubr_06220) 686647..686964 - 318 WP_212821397.1 helix-turn-helix transcriptional regulator Antitoxin
Prubr_RS03015 (Prubr_06230) 686957..687325 - 369 WP_212821399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Prubr_RS03020 (Prubr_06240) 687475..688389 + 915 WP_212821401.1 cation diffusion facilitator family transporter -
Prubr_RS03025 (Prubr_06250) 688686..689726 + 1041 WP_246568830.1 hypothetical protein -
Prubr_RS03030 (Prubr_06260) 689781..690338 - 558 WP_212821403.1 TetR/AcrR family transcriptional regulator -
Prubr_RS03035 (Prubr_06270) 690417..691499 + 1083 WP_212821412.1 FAD-dependent monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13943.77 Da        Isoelectric Point: 4.6651

>T37663 WP_212821399.1 NZ_AP023359:c687325-686957 [Polymorphospora rubra]
VGEAEWEIYVVDEVRDWIEGLDQASYDRVVQALDLLADVGPGLGRPLVDTIRGSRLAQLKELRPGTVRILFAFDPWRTSI
LLVAGDKAGHWNAWYREAIPLAEHRYEIYLKERAGMDGERHD

Download         Length: 369 bp

>T37663 NZ_AP023359:c687325-686957 [Polymorphospora rubra]
GTGGGGGAAGCCGAGTGGGAGATATACGTCGTCGACGAAGTGCGGGACTGGATCGAGGGATTGGATCAGGCGTCGTACGA
CCGAGTGGTGCAGGCACTTGATCTGCTTGCCGACGTTGGACCTGGTCTCGGCCGACCGCTGGTGGACACCATCCGCGGCT
CACGTCTCGCCCAACTGAAGGAGTTACGGCCGGGAACCGTACGCATCCTGTTCGCTTTCGATCCCTGGCGCACAAGTATT
CTCCTGGTCGCCGGCGACAAGGCGGGGCATTGGAACGCCTGGTATCGCGAAGCCATCCCGTTGGCTGAACACCGGTACGA
GATCTACCTCAAAGAGCGAGCCGGTATGGATGGAGAACGGCATGACTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11611.10 Da        Isoelectric Point: 7.0142

>AT37663 WP_212821397.1 NZ_AP023359:c686964-686647 [Polymorphospora rubra]
MTNYTRWKDIRSEYVARAGGEEAVEAGKQELLNEVLGYRLAEIRRARGLTQQEVADRMGVTKGRVSQIEQGKISGQDVLV
RFAAALGGRLHQAIYFDDGDISAIA

Download         Length: 318 bp

>AT37663 NZ_AP023359:c686964-686647 [Polymorphospora rubra]
ATGACTAACTACACCCGATGGAAGGACATCCGCTCGGAGTACGTCGCCCGTGCCGGGGGCGAGGAGGCCGTGGAGGCCGG
CAAGCAGGAACTGCTCAACGAGGTGCTGGGCTACCGGCTCGCCGAGATCCGCCGGGCACGAGGCCTCACCCAGCAGGAAG
TCGCCGACCGGATGGGGGTTACCAAGGGCCGCGTCTCGCAGATTGAGCAGGGGAAGATCTCCGGCCAGGACGTACTTGTC
CGGTTCGCTGCTGCGCTCGGTGGCCGCCTGCACCAGGCGATCTACTTCGACGACGGAGACATCTCCGCCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References