Detailed information of TA system TA037661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3430303..3430982
• Replicon: chromosome
• Accession: NZ_AP023358
• Organism: Micromonospora endophytica strain NBRC 109090

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Jiend_RS16165
• Protein ID: WP_111242289.1
• Coordinates: 3430617..3430982 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Jiend_RS16160
• Protein ID: WP_111242290.1
• Coordinates: 3430303..3430620 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Jiend_RS31320	3426438..3426704	+	267	WP_249412442.1	AHH domain-containing protein	-
Jiend_RS16135 (Jiend_33410)	3426797..3427258	+	462	WP_146603449.1	hypothetical protein	-
Jiend_RS16140 (Jiend_33420)	3427377..3427856	+	480	WP_212808282.1	DUF6346 domain-containing protein	-
Jiend_RS16145 (Jiend_33430)	3428146..3428481	+	336	WP_146603448.1	hypothetical protein	-
Jiend_RS16150	3428873..3429067	+	195	WP_146603447.1	hypothetical protein	-
Jiend_RS16155 (Jiend_33450)	3429219..3430124	+	906	WP_111242291.1	PKD domain-containing protein	-
Jiend_RS16160 (Jiend_33460)	3430303..3430620	-	318	WP_111242290.1	helix-turn-helix transcriptional regulator	Antitoxin
Jiend_RS16165 (Jiend_33470)	3430617..3430982	-	366	WP_111242289.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Jiend_RS16170 (Jiend_33480)	3431069..3432301	-	1233	WP_111242288.1	APC family permease	-
Jiend_RS16175 (Jiend_33490)	3432311..3433045	-	735	WP_181445038.1	phosphatase PAP2 family protein	-
Jiend_RS16180 (Jiend_33500)	3433293..3434501	+	1209	WP_111242303.1	DUF4032 domain-containing protein	-
Jiend_RS16185 (Jiend_33510)	3434508..3435617	-	1110	WP_111242287.1	N-acetylglucosamine-6-phosphate deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-87)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13824.81 Da
• Isoelectric Point: 4.7650

>T37661 WP_111242289.1 NZ_AP023358:c3430982-3430617 [Micromonospora endophytica]
MATDEWEIYLVKEVQEWIDSLDPLTHARVVQAIDLLAEAGPGLGRPLVDTIHGSSIANLKELRPGTVRILFAFDPWRSSI
LLVAGDKAGRWQQWYIEAIPLAEQRYEIYLKERAEEKGRQP

Nucleotide

• Length: 366 bp

>T37661 NZ_AP023358:c3430982-3430617 [Micromonospora endophytica]
ATGGCTACCGACGAGTGGGAGATCTACCTCGTCAAAGAGGTCCAGGAGTGGATCGACAGCCTCGATCCACTCACTCACGC
CCGCGTCGTGCAAGCCATCGACCTGCTCGCCGAAGCTGGCCCCGGGCTCGGCCGGCCGCTGGTCGACACGATCCACGGAT
CCTCGATCGCCAATCTCAAAGAGCTGCGCCCCGGCACCGTACGCATCCTGTTCGCCTTCGACCCGTGGCGCTCCAGCATC
CTGCTCGTCGCCGGAGACAAGGCCGGACGCTGGCAGCAGTGGTACATCGAAGCGATCCCCCTGGCCGAGCAACGCTACGA
GATCTACCTTAAGGAACGCGCCGAGGAGAAGGGACGACAGCCGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11313.69 Da
• Isoelectric Point: 8.5684

>AT37661 WP_111242290.1 NZ_AP023358:c3430620-3430303 [Micromonospora endophytica]
VSSYARWSDIRAAHVERAGGEEAVEAGKQELLTNVVGHRLAEVRRARGLTQQQVADRMGVTKGRVSQIEQGKISGQDIVA
RYAAALGGRLHQAIYFDDGDIAAIA

Nucleotide

• Length: 318 bp

>AT37661 NZ_AP023358:c3430620-3430303 [Micromonospora endophytica]
GTGAGCAGCTATGCACGCTGGAGCGACATCCGCGCCGCCCACGTCGAACGCGCCGGCGGCGAAGAGGCCGTCGAAGCAGG
CAAGCAGGAGCTACTCACCAACGTCGTCGGACACCGCCTCGCCGAGGTACGGCGCGCCCGTGGCCTAACCCAACAGCAGG
TCGCCGACCGCATGGGCGTCACCAAAGGCCGCGTCTCCCAAATCGAACAGGGTAAAATCTCCGGCCAAGACATCGTCGCC
CGCTACGCCGCCGCCCTCGGCGGACGCCTCCACCAAGCCATCTACTTCGACGATGGCGACATCGCCGCCATCGCATAG