Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2225833..2226257 Replicon chromosome
Accession NZ_AP023354
Organism Actinocatenispora sera strain NBRC 101916

Toxin (Protein)


Gene name yoeB Uniprot ID A0A810KXU7
Locus tag Asera_RS10765 Protein ID WP_030446810.1
Coordinates 2225833..2226093 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Asera_RS33030 Protein ID WP_280529724.1
Coordinates 2226090..2226257 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Asera_RS10740 (Asera_21540) 2221006..2221293 - 288 WP_030446806.1 YciI family protein -
Asera_RS10750 (Asera_21550) 2221456..2223516 + 2061 WP_030446807.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
Asera_RS10755 (Asera_21560) 2223661..2224695 - 1035 WP_030446808.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
Asera_RS10760 (Asera_21570) 2224874..2225821 + 948 WP_030446809.1 DJ-1/PfpI family protein -
Asera_RS10765 (Asera_21580) 2225833..2226093 - 261 WP_030446810.1 Txe/YoeB family addiction module toxin Toxin
Asera_RS33030 (Asera_21590) 2226090..2226257 - 168 WP_280529724.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Asera_RS10775 (Asera_21600) 2226341..2227381 - 1041 WP_030446812.1 aldo/keto reductase family protein -
Asera_RS10780 (Asera_21610) 2227489..2229642 + 2154 WP_051802347.1 Hsp70 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-46)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10358.70 Da        Isoelectric Point: 7.3571

>T37654 WP_030446810.1 NZ_AP023354:c2226093-2225833 [Actinocatenispora sera]
VILIWDGSAWDDYLWWQQQDRKVLRRINLLIKDIDRNGNEGLGKPEPLKHGFHGYWSRRITDEHRLVSRIEGDEIRIAAC
RYHYEA

Download         Length: 261 bp

>T37654 NZ_AP023354:c2226093-2225833 [Actinocatenispora sera]
GTGATCCTGATCTGGGATGGCAGCGCCTGGGACGACTACCTGTGGTGGCAGCAACAGGATCGCAAGGTACTCAGGCGGAT
CAACTTGTTGATCAAGGATATCGACCGGAACGGCAACGAGGGGCTCGGAAAACCCGAGCCCCTCAAGCATGGCTTCCACG
GGTACTGGTCCCGCCGCATCACCGATGAGCATCGACTGGTGTCTCGGATCGAGGGCGACGAGATCCGCATCGCCGCCTGC
CGCTACCACTACGAGGCTTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6221.00 Da        Isoelectric Point: 5.0035

>AT37654 WP_280529724.1 NZ_AP023354:c2226257-2226090 [Actinocatenispora sera]
VTRAGHEPVVIVSLDDYESLKETAYLLRNPANARRLLASIERLERGEGSQRDLIE

Download         Length: 168 bp

>AT37654 NZ_AP023354:c2226257-2226090 [Actinocatenispora sera]
GTGACGCGAGCAGGCCACGAACCTGTCGTGATTGTCTCGCTGGACGACTACGAATCGTTGAAGGAGACGGCGTACCTGCT
GCGGAACCCCGCCAACGCGCGCCGCCTGCTGGCGTCGATCGAACGCCTGGAACGTGGCGAAGGCTCGCAGCGGGATCTGA
TCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A810KXU7

Antitoxin

Source ID Structure

References