Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 838745..839333 Replicon chromosome
Accession NZ_AP023344
Organism Helicobacter pylori strain JSHR3

Toxin (Protein)


Gene name TfiT Uniprot ID M3P300
Locus tag M2Y48_RS04030 Protein ID WP_000921941.1
Coordinates 838745..839026 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E6NQF6
Locus tag M2Y48_RS04035 Protein ID WP_000065312.1
Coordinates 839019..839333 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2Y48_RS03995 (JSHR3_08230) 833913..834176 + 264 WP_000564648.1 hypothetical protein -
M2Y48_RS04000 (JSHR3_08240) 834173..834472 + 300 WP_000660136.1 hypothetical protein -
M2Y48_RS04005 (JSHR3_08250) 834472..835414 + 943 Protein_792 ATPase, T2SS/T4P/T4SS family -
M2Y48_RS04010 (JSHR3_08260) 835411..835866 + 456 WP_096396225.1 mobilization protein -
M2Y48_RS04015 (JSHR3_08270) 835863..836153 + 291 WP_096396223.1 hypothetical protein -
M2Y48_RS04020 (JSHR3_08280) 836154..836711 + 558 WP_248419536.1 hypothetical protein -
M2Y48_RS04025 (JSHR3_08290) 836712..838439 + 1728 WP_248419537.1 type IV secretory system conjugative DNA transfer family protein -
M2Y48_RS04030 (JSHR3_08300) 838745..839026 - 282 WP_000921941.1 YafQ family addiction module toxin Toxin
M2Y48_RS04035 (JSHR3_08310) 839019..839333 - 315 WP_000065312.1 hypothetical protein Antitoxin
M2Y48_RS04040 (JSHR3_08320) 839618..841384 + 1767 WP_248419539.1 relaxase -
M2Y48_RS04045 (JSHR3_08330) 841409..842572 - 1164 WP_248419541.1 hypothetical protein -
M2Y48_RS04050 (JSHR3_08340) 842604..842888 - 285 WP_000394633.1 hypothetical protein -
M2Y48_RS04055 (JSHR3_08350) 842970..843626 - 657 WP_000587395.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cds6 / cag1 / cag3 / virB1 / virD4 / virB11 / cagZ / virB10/cagY / virB9/cagX / virB6/cagW / virB8/cagV / cagU / virB7/cagT / cagS / cagQ / cagP / cagM / cagN / virB5/cagL / cagI / cagH / cagG / cagF / virB4/cagE / cagD / virB2/cagC / cagA / fliN / cheV3 / flaA / hopH / flgR / fliP / wbpB / futA / hopH 655832..937099 281267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10891.80 Da        Isoelectric Point: 9.5726

>T37642 WP_000921941.1 NZ_AP023344:c839026-838745 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T37642 NZ_AP023344:c839026-838745 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAGCAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12186.65 Da        Isoelectric Point: 4.9309

>AT37642 WP_000065312.1 NZ_AP023344:c839333-839019 [Helicobacter pylori]
MSNIITDYSQYNEKQLYNLLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT37642 NZ_AP023344:c839333-839019 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTATTCGCAATACAATGAAAAGCAACTGTACAATTTATTAAACGCCATTGAAAAACAATG
GCTTAAGGCAGAAGGGGATAAAAACAAGGCAATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTCTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGCTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M3P300

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q2QNU5

References