Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 21910..22451 Replicon plasmid pAAJCM20276_3
Accession NZ_AP023329
Organism Acetobacter aceti strain JCM20276

Toxin (Protein)


Gene name yoeB Uniprot ID G2I8S5
Locus tag AAJCM20276_RS18275 Protein ID WP_014106724.1
Coordinates 21910..22179 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G2I8S6
Locus tag AAJCM20276_RS18280 Protein ID WP_010668421.1
Coordinates 22176..22451 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAJCM20276_RS18250 17399..18244 - 846 WP_007396167.1 IS21-like element helper ATPase IstB -
AAJCM20276_RS18255 18241..19491 - 1251 WP_007396168.1 IS21 family transposase -
AAJCM20276_RS18260 19637..19978 - 342 Protein_25 lactate dehydrogenase -
AAJCM20276_RS18265 20018..21111 - 1094 Protein_26 Fic family protein -
AAJCM20276_RS18270 21227..21897 - 671 Protein_27 hypothetical protein -
AAJCM20276_RS18275 21910..22179 - 270 WP_014106724.1 Txe/YoeB family addiction module toxin Toxin
AAJCM20276_RS18280 22176..22451 - 276 WP_010668421.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AAJCM20276_RS18285 22677..22814 - 138 WP_014106725.1 hypothetical protein -
AAJCM20276_RS18290 22840..23232 - 393 WP_010668423.1 PIN domain nuclease -
AAJCM20276_RS18295 23229..23423 - 195 WP_010516209.1 type II toxin-antitoxin system VapB family antitoxin -
AAJCM20276_RS18300 23478..26565 - 3088 Protein_33 Ti-type conjugative transfer relaxase TraA -
AAJCM20276_RS18305 27216..27365 + 150 WP_185230135.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45372 45372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10563.91 Da        Isoelectric Point: 7.3582

>T37608 WP_014106724.1 NZ_AP023329:c22179-21910 [Acetobacter aceti]
VKVIFHEDGWEDYLSWFQSDNAVLEKINALIEDVRRHPFQGIGKPEPLKGQLSGWWSRRITGEHRLVYRVQGRAGEDQRI
EIAQCRFHY

Download         Length: 270 bp

>T37608 NZ_AP023329:c22179-21910 [Acetobacter aceti]
GTGAAAGTCATTTTTCATGAAGATGGCTGGGAGGATTATCTTTCGTGGTTTCAGTCAGACAATGCGGTTCTTGAGAAGAT
CAATGCCCTGATCGAGGATGTGCGTCGGCATCCGTTTCAGGGGATAGGGAAGCCGGAACCCCTGAAGGGGCAGCTTTCTG
GGTGGTGGTCCCGACGGATTACGGGAGAACATCGTCTGGTCTACCGGGTTCAGGGGCGCGCGGGAGAGGATCAGCGAATC
GAGATTGCCCAGTGCCGGTTTCATTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10206.37 Da        Isoelectric Point: 5.1070

>AT37608 WP_010668421.1 NZ_AP023329:c22451-22176 [Acetobacter aceti]
MTYVSYTDLRQNLAHYLDEAVNSRAPIVVTRKTGKGSVVLMSEEEFSGWQETVHLLSSPRNAERLLRSIRDIEHGAATEH
DLLEPQGEPSA

Download         Length: 276 bp

>AT37608 NZ_AP023329:c22451-22176 [Acetobacter aceti]
ATGACCTATGTTTCCTATACCGACCTGCGCCAGAACCTGGCGCATTATCTGGACGAAGCAGTGAACAGCCGTGCGCCGAT
TGTCGTGACCCGCAAGACCGGGAAAGGCAGTGTCGTGCTGATGTCGGAAGAAGAATTCTCCGGCTGGCAGGAAACCGTGC
ATCTCCTGAGCAGCCCACGCAACGCGGAGAGGCTGTTGCGGAGCATTCGTGACATCGAGCACGGGGCGGCAACCGAGCAT
GATCTTCTGGAGCCTCAGGGTGAACCGTCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A149R123

Antitoxin

Source ID Structure
AlphaFold DB A0A149R124

References