Detailed information of TA system TA037573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4782906..4783508
• Replicon: chromosome
• Accession: NZ_AP023317
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5693_RS23325
• Protein ID: WP_001159630.1
• Coordinates: 4783197..4783508 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5693_RS23320
• Protein ID: WP_000362050.1
• Coordinates: 4782906..4783196 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5693_RS23305 (4780399)	4780399..4781301	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5693_RS23310 (4781298)	4781298..4781933	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5693_RS23315 (4781930)	4781930..4782859	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5693_RS23320 (4782906)	4782906..4783196	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5693_RS23325 (4783197)	4783197..4783508	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5693_RS23330 (4783726)	4783726..4784655	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5693_RS23335 (4784741)	4784741..4785052	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5693_RS23340 (4785049)	4785049..4785495	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5693_RS23345 (4785510)	4785510..4786451	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5693_RS23350 (4786496)	4786496..4786933	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5693_RS23355 (4786930)	4786930..4787802	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5693_RS23360 (4787796)	4787796..4788395	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37573 WP_001159630.1 NZ_AP023317:c4783508-4783197 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37573 NZ_AP023317:c4783508-4783197 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37573 WP_000362050.1 NZ_AP023317:c4783196-4782906 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37573 NZ_AP023317:c4783196-4782906 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64