Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428219..2428741 Replicon chromosome
Accession NZ_AP023315
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4614

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5684_RS11880 Protein ID WP_000221343.1
Coordinates 2428457..2428741 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5684_RS11875 Protein ID WP_000885424.1
Coordinates 2428219..2428467 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5684_RS11850 (2423435) 2423435..2424901 + 1467 WP_000987828.1 hypothetical protein -
K5684_RS11855 (2425709) 2425709..2426423 + 715 Protein_2332 helix-turn-helix domain-containing protein -
K5684_RS11860 (2426479) 2426479..2427387 - 909 WP_010989018.1 hypothetical protein -
K5684_RS11865 (2427530) 2427530..2427862 - 333 WP_000253154.1 DUF1493 family protein -
K5684_RS11870 (2427852) 2427852..2428067 - 216 WP_000206207.1 hypothetical protein -
K5684_RS11875 (2428219) 2428219..2428467 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5684_RS11880 (2428457) 2428457..2428741 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5684_RS11885 (2428912) 2428912..2429301 + 390 WP_000194089.1 RidA family protein -
K5684_RS11890 (2429353) 2429353..2430432 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5684_RS11895 (2430625) 2430625..2431113 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5684_RS11900 (2431158) 2431158..2432666 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2423438..2435523 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37540 WP_000221343.1 NZ_AP023315:2428457-2428741 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37540 NZ_AP023315:2428457-2428741 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37540 WP_000885424.1 NZ_AP023315:2428219-2428467 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37540 NZ_AP023315:2428219-2428467 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References